Table 1.

Effects of ICE-like caspase inhibitor (YVAD.CMK) and a relatively selective CPP32-like caspase inhibitor (z-DEVD.FMK) on infarct volume and neurological deficits after temporary MCA occlusion (2 hr) and reperfusion (18 hr)

Treatments	n	Infarct volume, mm3	Neurological deficits
Vehicle	8	100  ±  9	1.8  ±  0.2
YVAD.CMK (200 ng)	6	96  ±  13	1.5  ±  0.3
YVAD.CMK (400 ng)	6	36  ±  18**	0.8  ±  0.4*
Vehicle	10	90  ±  6	2.1  ±  0.1
z-DEVD.FMK (80 ng)	10	83  ±  7	1.6  ±  0.2
z-DEVD.FMK (240 ng)	9	66  ±  8*	1.1  ±  0.3**

Neurological deficits were decreased by YVAD.CMK and z-DEVD.FMK after 18 hr, although no significant group differences were detected at 10 min or 2 hr of ischemia (data not shown). Data are presented as means ± SE. ∗, P < 0.05; ∗∗, P < 0.01 vs. vehicle.