Figure 3.

GPI-1046 increases striatal TH+ innervation density after intranigral 6-OHDA injection. The dense pattern of TH+ punctae and processes that characterize the normal caudate putamen is evident in the caudate putamen contralateral to the 6-OHDA injection (Left). Extensive loss of TH+ punctae is evident in the striatum ipsilateral to the 6-OHDA injection (Center), but a sparse network of TH+ fibers are spared (Right). In cases treated with daily GPI-1046 (10 mg/kg, s.c.) for 5 days beginning 1 week after the 6-OHDA injection, an increase in the density of TH+ labeled fibers is evident together with an increase in the number of TH+ varicosities. Veh, vehicle.