Table 3.

GPI-1046 reverses rotational motor abnormalities in 6-OHDA lesioned rats

Treatment	Duration of rotations, min	Rate of rotations, rotations/hr
Vehicle/vehicle	0	0
6-OHDA/vehicle	28.0 ± 8.0	192.0 ± 52.7
6-OHDA/GPI-1046	2.3 ± 1.5*	65.0 ± 15.5*

6-OHDA lesioned animals treated with GPI-1046 (10 mg/kg, s.c.) 1 week postlesion were evaluated for their response to amphetamine-induced rotation 14 days following their last GPI-1046 treatment. On day 11 after the last GPI-1046 treatment, the rats were given 3 mg/kg amphetamine as a sensitizing dose. On day 14 following GPI-1046, animals were treated with 3 mg/kg amphetamine, and their rotational behavior was quantitated by manual observation. The mean values ± SEM for duration of rotation and maximal rate of rotation are presented. ∗, Results are statistically significantly different from 6-OHDA/vehicle; P < 0.05.