Table 3.

Amounts of paclitaxel and metabolites excreted by mice with cannulated gall bladder within 90 min after i.v. administration of [³H]paclitaxel

Sample	Compound	Dose, 10 mg/kg		Dose, 5 mg/kg
		Wild type	mdr1a(−/−)	Wild type	mdr1a(−/−)
Plasma (level, ng/ml)	Paclitaxel	2020 ± 420	2370 ± 280	289 ± 38	327 ± 44
Bile	Paclitaxel	4.81 ± 0.27	2.56 ± 0.58	5.94 ± 1.70	4.10 ± 0.54
	3′-p-hydroxypaclitaxel	2.86 ± 0.28	2.48 ± 0.26	4.74 ± 0.69	4.10 ± 0.18
	6α-hydroxypaclitaxel	2.00 ± 0.25	1.29 ± 0.24	3.25 ± 0.51	1.98 ± 0.22
	3H label	17.9 ± 0.69	15.0 ± 1.5	25.7 ± 4.5	26.6 ± 2.90
Intestinal contents	Paclitaxel	10.77 ± 0.25	2.49 ± 0.86*	3.53 ± 0.38	0.98 ± 0.28*
	3-p-hydroxypaclitaxel†
	6α-hydroxypaclitaxel	0.37 ± 0.10	0.37 ± 0.16	0.16 ± 0.05	<0.1
	3H label	12.22 ± 0.28	3.79 ± 1.11*	4.63 ± 0.49	1.52 ± 0.05

Excretion is given as percentage of the dose (mean ± SEM; n = 4). ND, Not detectable. 

^*P < 0.05. 

^†This compound could not be accurately quantified in the intestinal contents due to the presence of an interfering substance.