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Inhibition of rat and human FAAH by CF3-OH
| Enzyme | Rate of hydrolysis, nmol·min−1·mg−1 | % |
|---|---|---|
| Rat FAAH | 30.7 ± 1.5 | 100 |
| Rat FAAH + CF3-OH | 5.2 + 0.8 | 16.8 |
| Human FAAH | 21.5 + 0.9 | 100 |
| Human FAAH + CF3-OH | 4.3 + 0.5 | 19.8 |
Relative inhibition of rat and human FAAH activity by 10 μM CF3-OH. Oleamide (100 μM) was used as substrate in each assay.
