Table 3.
Site and strand specificity of spontaneous and UV-induced mutations
| Mutation site* | No. of spontaneous events (sense or antisense strand)‡ | Spontaneous base change†‡ | No. of induced events (sense or antisense strand)†‡ | Induced base change‡ |
|---|---|---|---|---|
| TCA/G | 0 | — | 20 (8s, 12a) | C to :T(16) :A(3) :G(1) |
| CTA/G | 1 (s) | T to G | 2 (1s, 1a) | T to :C(2) |
| GCC | 2 (1s, 1a) | C to :T(1) :A(1) | 1 (a) | C to A |
| TTG | 0 | — | 1 (s) | T to C |
| CCG | 1 (a) | C to A | 0 | — |
| Total at dipyrimidines | 4 | 24 | ||
| TCC | 1 (a) | C to A | 12 (2s, 10a) | C to :T(10) :A(2) |
| TCT | 0 | — | 7 (2s, 5a) | C to :T(6) :G(1) |
| CCC | 1 (s) | C to T | 3 (1s, 2a) | C to :T(2) :A(1) |
| TTC | 1 (a) | T to G | 0 | — |
| Total at overlapping dipyrimidines | 3 | 22 | ||
| ACA/G | 4 | C to :T(3) :A(1) | 4 | C to :T(3) :G(1) |
| GCA | 0 | — | 1 | C to T |
| ATG | 1 | T to C | 0 | — |
| Total at nondipyrimidines | 5 | 5 |
*
Mutated bases are underlined.
†
Mutations resulting from UV photoproducts on the (s)ense or (a)ntisense strand.
‡
Number of events is in parentheses.