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. 1997 Mar 18;94(6):2278–2283. doi: 10.1073/pnas.94.6.2278

Figure 4.

Figure 4

Analysis of ligand cross talk. The effects of ligand binding to heterodimer and binding of one ligand to one receptor to the binding of another ligand to another receptor in the coexpressed RXR and RAR heterodimer system. (a) The ligands do not dissociate the RXR–RAR heterodimer. (Lanes 1–8) DMSO, 9-cis-RA, t-RA, LG550, LG628, LG69, LG268, and LG754. (b) Binding of RXR-specific agonists or antagonist to RXR LBD would not significantly affect the binding of RAR-specific ligand t-RA to RAR LBD. (c) Binding of RAR-specific agonists or antagonist would not significantly affect the binding of RXR-specific ligand LG69 to RXR LBD.