Table 2.
Patient outcomes | Midazolam (n=151) | Haloperidol-promethazine (n=150) | Relative risk (CI)* | Difference in % risk (CI)* |
---|---|---|---|---|
By 20 minutes after injection | ||||
Tranquil or asleep | 134 (89) | 101 (67) | 1.32 (1.16 to 1.49) | 22 (12 to 30) |
Asleep | 93 (62) | 43 (29) | 2.15 (1.48 to 3.11) | 33 (19 to 47) |
Serious adverse effect | 1 (1) | 1 (1) | ||
Unknown | 1 (1) | 2 (1) | ||
By 40 minutes after injection | ||||
Tranquil or asleep | 141 (93) | 124 (83) | 1.13 (1.01 to 1.26) | 10 (1 to 20) |
Asleep | 118 (78) | 69 (46) | 1.70 (1.32 to 2.19) | 32 (18 to 46) |
Unknown | 1 (1) | 2 (1) | ||
By 60 minutes after injection | ||||
Tranquil or asleep | 141 (93) | 131 (87) | 1.07 (0.97 to 1.18) | 6 (−3 to 15) |
Asleep | 120 (79) | 83 (55) | 1.44 (1.16 to 1.78) | 24 (11 to 38) |
Unknown | 1 (1) | 2 (1) | ||
By 120 minutes after injection | ||||
Tranquil or asleep | 144 (95) | 138 (92) | 1.04 (0.96 to 1.12) | 3 (−4 to 11) |
Asleep | 125 (83) | 95 (63) | 1.31 (1.08 to 1.57) | 20 (7 to 32) |
No additional tranquillising drugs | 149 (99) | 143 (95) | 1.04 (0.98 to 1.09) | 4 (−2 to 8) |
Not needing restraints | 118 (78) | 110 (73) | 1.07 (0.90 to 1.26) | 5 (−8 to 18) |
Unknown | 1 (1) | 2 (1) | ||
By 24 hours after injection | ||||
No other episode of aggression: | 107 (71) | 111 (74) | 0.96 (0.80 to 1.15) | −3 (−16 to 10) |
Unknown | 2 (1) | 7 (5) | ||
Doctor not called to see patient: | 100 (66) | 107 (71) | 0.93 (0.76 to 1.13) | −5 (−19 to 8) |
Unknown | 2 (1) | 4 (3) | ||
Accepting oral medication: | 135 (89) | 139 (93) | 0.96 (0.88 to 1.06) | −4 (−12 to 5) |
Unknown | 7 (5) | 5 (3) | ||
By 2 weeks after injection | ||||
Discharged | 73 (48) | 69 (46) | 1.05 (0.77 to 1.44) | 2 (−12 to 17) |
Unknown | 0 | 3 (2) |
99% confidence intervals, except for primary outcome (tranquil or asleep by 20 minutes), which is 95%.