Skip to main content
PMC home page
British Journal of Cancer logoLink to British Journal of Cancer
. 1973 Apr;27(4):276–282. doi: 10.1038/bjc.1973.34

The Frequency of M-components in Sera of Patients with Solid Malignant Neoplasms

A Talerman, W G Haije
PMCID: PMC2008789  PMID: 4633840

Abstract

The frequency of M-components was studied by agar gel electrophoresis in sera from 807 patients, 467 (57%) females and 340 (43%) males with histologically proven solid malignant neoplasms.

M-components were found in the sera of 40 male and 20 female patients. Apart from two known cases of multiple myeloma and one case of Waldenström's macroglobulinaemia, none of the patients were found to be suffering from these diseases. The frequency of M-components increased with age, and this was more evident in males. Twenty-two of 60 patients with M-components did not exhibit abnormalities on immunoelectrophoresis. Of the 35 remaining patients, 27 had an abnormal component of the IgG class, 6 of the IgA and 2 of the IgM class. M-components were found in the sera of patients with a wide variety of neoplasms. There appeared to be no evidence of an increased frequency of M-components in the sera of patients with solid malignant neoplasms compared with normal adult population.

Full text

PDF
276

Images in this article

278Fig. 1
on p.278

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AZAR H. A., HILL W. T., OSSERMAN E. F. Malignant lymphoma and lymphatic leukemia associated with myeloma-type serum proteins. Am J Med. 1957 Aug;23(2):239–249. doi: 10.1016/0002-9343(57)90197-3. [DOI] [PubMed] [Google Scholar]
  2. Axelsson U., Bachmann R., Hällén J. Frequency of pathological proteins (M-components) om 6,995 sera from an adult population. Acta Med Scand. 1966 Feb;179(2):235–247. doi: 10.1111/j.0954-6820.1966.tb05453.x. [DOI] [PubMed] [Google Scholar]
  3. Axelsson U., Hällén J. A population study on monoclonal gammapathy. Follow-up after 5 and one-half years on 64 subjects detected by electrophoresis of 6995 sera. Acta Med Scand. 1972 Jan-Feb;191(1-2):111–113. [PubMed] [Google Scholar]
  4. Derycke C., Fine J. M., Boffa G. A. Dysglobulinémies "essentielles" chez les sujets agés. Nouv Rev Fr Hematol. 1965 Sep-Oct;5(5):729–738. [PubMed] [Google Scholar]
  5. Fine J. M., Lambin P., Leroux P. Frequency of monoclonal gammapathy ('M components') in 13,400 sera from blood donors. Vox Sang. 1972;23(4):336–343. doi: 10.1111/j.1423-0410.1972.tb03468.x. [DOI] [PubMed] [Google Scholar]
  6. Fine J. M. Study of the frequency of kappa and lambda light chains in 347 sera containing a monoclonal IgG, IgA, IgD, or Bence-Jones protein. Rev Eur Etud Clin Biol. 1970 Feb;15(2):199–202. [PubMed] [Google Scholar]
  7. HALLEN J. Frequency of "abnormal" serum globulins (M-components) in the aged. Acta Med Scand. 1963 Jun;173:737–744. [PubMed] [Google Scholar]
  8. Hosley H. F. M-proteins, plasmacytosis and cancer. Cancer. 1967 Feb;20(2):295–307. doi: 10.1002/1097-0142(1967)20:2<295::aid-cncr2820200217>3.0.co;2-1. [DOI] [PubMed] [Google Scholar]
  9. Kano T. The behavior of immunoglobulin in monoclonal gammopathies and their classification and pathogenesis. Tohoku J Exp Med. 1970 Dec;102(4):369–401. [PubMed] [Google Scholar]
  10. Michaux J. L., Heremans J. F. Thirty cases of monoclonal immunoglobulin disorders other than myeloma or macroglobulinemia. A classification of diseases associated with the production of monoclonal-type immunoglobulins. Am J Med. 1969 Apr;46(4):562–579. doi: 10.1016/0002-9343(69)90075-8. [DOI] [PubMed] [Google Scholar]
  11. Migliore P. J., Alexanian R. Monoclonal gammopathy in human neoplasia. Cancer. 1968 Jun;21(6):1127–1131. doi: 10.1002/1097-0142(196806)21:6<1127::aid-cncr2820210613>3.0.co;2-0. [DOI] [PubMed] [Google Scholar]
  12. Moore D. F., Migliore P. J., Shullenberger C. C., Alexanian R. Monoclonal macroglobulinemia in malignant lymphoma. Ann Intern Med. 1970 Jan;72(1):43–47. doi: 10.7326/0003-4819-72-1-43. [DOI] [PubMed] [Google Scholar]
  13. OSSERMAN E. F., TAKATSUKI K. PLASMA CELL MYELOMA: GAMMA GLOBULIN SYNTHESIS AND STRUCTURE. A REVIEW OF BIOCHEMICAL AND CLINICAL DATA, WITH THE DESCRIPTION OF A NEWLY-RECOGNIZED AND RELATED SYNDROME, "H-GAMMA-2-CHAIN (FRANKLIN'S) DISEASE. Medicine (Baltimore) 1963 Nov;42:357–384. [PubMed] [Google Scholar]
  14. OWEN J. A., PITNEY W. R., O'DEA J. F. "Myeloma" serum electrophoretic patterns in conditions other than myelomatosis. J Clin Pathol. 1959 Jul;12:344–350. doi: 10.1136/jcp.12.4.344. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. SCHEIDEGGER J. J. Une micro-méthode de l'immuno-electrophorèse. Int Arch Allergy Appl Immunol. 1955;7(2):103–110. [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES