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Survival of TIMP-3–null mice is compromised. (a) Beginning at 56 weeks of age, individual TIMP-3–null mice became overtly sick, and by 83 weeks of age all animals in this study were sacrificed. This compared with heterozygote controls (Hets), which lived illness free for at least 120 weeks. Shown is pooled data for both males and females. (b) Sex-specific differences in survival (TIMP-3–/– males, n = 10; TIMP-3–/– females, n = 10; TIMP-3+/– males, n = 3).
