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. 1974 Dec;30(6):560–565. doi: 10.1038/bjc.1974.235

Radiosensitization of C3H Mouse Mammary Tumours by a 2-Nitroimidazole Drug

P W Sheldon, J L Foster, J F Fowler
PMCID: PMC2009326  PMID: 4451633

Abstract

Local tumour control has been determined at 150 days after single doses of 240 kV x-rays given with or without 1 mg/g body weight of the hypoxic cell radiosensitizer Ro-07-0582. The dose required to control 50% of the tumours (TCD50) was reduced from 4380 to 2410 rad, yielding an enhancement ratio of 1·82 ± 0·07 s.e.mean. This compares favourably with the corresponding single dose gain factor for fast neutrons, which was about 1·7.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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