Skip to main content
PMC home page
British Journal of Cancer logoLink to British Journal of Cancer
. 1978 Sep;38(3):375–381. doi: 10.1038/bjc.1978.217

Restricted autologous lymphocytotoxicity in lung neoplasia.

B M Vose, F Vánky, M Fopp, E Klein
PMCID: PMC2009731  PMID: 81674

Abstract

Blood lymphocytes from 47 patients with lung carcinoma have been tested for cytotoxicity against cells isolated from the autologous tumour. Significant cytotoxic potential was found in 15 cases. The effectors were also tested against allogeneic tumour targets from lung and other sites. Reactions were only rarely detected (2/32 positive against lung and 1/13 positive against non-lung cells). The restriction of cytotoxicity to the autologous combination was also apparent in in vitro-generated effectors. Blood lymphocytes were co-cultivated with autologous tumour and subsequently tested against autologous or allogeneic targets. Cytotoxicity was found in 13/17 lung tumours against autologous tumour, with no reactions recorded against allogeneic tumour targets, but one case positive against the K562 cell line. These data suggest either the expression of individually distinct antigens on human pulmonary neoplasms, or the requirement for histocompatibility between target and effector in cytotoxicity reactions in man, and therefore differ from previously described patterns of lymphocytotoxicity against human tumours.

Full text

PDF
375

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baldwin R. W., Embleton M. J., Jones J. S., Langman M. J. Cell-mediated and humoral immune reactions to human tumours. Int J Cancer. 1973 Jul 15;12(1):73–83. doi: 10.1002/ijc.2910120108. [DOI] [PubMed] [Google Scholar]
  2. Boddie A. W., Jr, Holmes E. C., Roth J. A., Morton D. L. Inhibition of human leukocyte migration in agarose by kcl extracts of carcinoma of the lung. Int J Cancer. 1975 May 15;15(5):823–829. doi: 10.1002/ijc.2910150514. [DOI] [PubMed] [Google Scholar]
  3. Currie G. A., Lejeune F., Fairley G. H. Immunization with irradiated tumour cells and specific lymphocyte cytotoxicity in malignant melanoma. Br Med J. 1971 May 8;2(5757):305–310. doi: 10.1136/bmj.2.5757.305. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Dalbow M. H., Concannon J. P., Eng C. P., Weil C. S., Conway J., Narayanan Nambisan P. T. Lymphocyte mitogen stimulation studies for patients with lung cancer: evaluation of prognostic significance of preirradiation therapy studies. J Lab Clin Med. 1977 Aug;90(2):295–302. [PubMed] [Google Scholar]
  5. Dickmeiss E., Soeberg B., Svejgaard A. Human cell-mediated cytotoxicity against modified target cells is restricted by HLA. Nature. 1977 Dec 8;270(5637):526–528. doi: 10.1038/270526a0. [DOI] [PubMed] [Google Scholar]
  6. Eilber F. R., Morton D. L. Impaired immunologic reactivity and recurrence following cancer surgery. Cancer. 1970 Feb;25(2):362–367. doi: 10.1002/1097-0142(197002)25:2<362::aid-cncr2820250213>3.0.co;2-v. [DOI] [PubMed] [Google Scholar]
  7. Goulmy E., Termijtelen A., Bradley B. A., van Rood J. J. Y-antigen killing by T cells of women is restricted by HLA. Nature. 1977 Apr 7;266(5602):544–545. doi: 10.1038/266544a0. [DOI] [PubMed] [Google Scholar]
  8. Hellström I., Hellström K. E., Sjögren H. O., Warner G. A. Demonstration of cell-mediated immunity to human neoplasms of various histological types. Int J Cancer. 1971 Jan 15;7(1):1–16. doi: 10.1002/ijc.2910070102. [DOI] [PubMed] [Google Scholar]
  9. Hollinshead A. C., Stewart T. H., Herberman R. B. Delayed-hypersensitivity reactions to soluble membrane antigens of human malignant lung cells. J Natl Cancer Inst. 1974 Feb;52(2):327–338. doi: 10.1093/jnci/52.2.327. [DOI] [PubMed] [Google Scholar]
  10. Julius M. H., Simpson E., Herzenberg L. A. A rapid method for the isolation of functional thymus-derived murine lymphocytes. Eur J Immunol. 1973 Oct;3(10):645–649. doi: 10.1002/eji.1830031011. [DOI] [PubMed] [Google Scholar]
  11. Lozzio C. B., Lozzio B. B. Cytotoxicity of a factor isolated from human spleen. J Natl Cancer Inst. 1973 Feb;50(2):535–538. doi: 10.1093/jnci/50.2.535. [DOI] [PubMed] [Google Scholar]
  12. Pierce G. E., DeVald B. L. Effects of human lymphocytes on cultured normal and malignant cells. Cancer Res. 1975 Jul;35(7):1830–1839. [PubMed] [Google Scholar]
  13. Pross H. F., Baines M. G. Spontaneous human lymphocyte-mediated cytotoxicity againts tumour target cells. I. The effect of malignant disease. Int J Cancer. 1976 Nov 15;18(5):593–604. doi: 10.1002/ijc.2910180508. [DOI] [PubMed] [Google Scholar]
  14. Takasugi M., Mickey M. R., Terasaki P. I. Reactivity of lymphocytes from normal persons on cultured tumor cells. Cancer Res. 1973 Nov;33(11):2898–2902. [PubMed] [Google Scholar]
  15. Takasugi M., Ramseyer A., Takasugi J. Decline of natural nonselective cell-mediated cytotoxicity in patients with tumor progression. Cancer Res. 1977 Feb;37(2):413–418. [PubMed] [Google Scholar]
  16. Vose B. M., Kimber I., Moore M. Leukocyte migration inhibition in human pulmonary neoplasia. J Natl Cancer Inst. 1977 Mar;58(3):483–488. doi: 10.1093/jnci/58.3.483. [DOI] [PubMed] [Google Scholar]
  17. Vose B. M., Moore M., Jack G. D. Cell-mediated cytotoxicity to human pulmonary neoplasms. Int J Cancer. 1975 Feb 15;15(2):308–320. doi: 10.1002/ijc.2910150216. [DOI] [PubMed] [Google Scholar]
  18. Vose B. M., Moore M. Reactivity of peripheral blood leukocytes against human foetal cells. II. Cytotoxic potential of preparations enriched or depleted of different leukocyte populations. Int J Cancer. 1977 Jan;19(1):34–42. doi: 10.1002/ijc.2910190106. [DOI] [PubMed] [Google Scholar]
  19. Vose B. M., Vanky F., Klein E. Lymphocyte cytotoxicity against autologous tumour biopsy cells in humans. Int J Cancer. 1977 Oct 15;20(4):512–519. doi: 10.1002/ijc.2910200407. [DOI] [PubMed] [Google Scholar]
  20. Vose B. M., Vánky F., Fopp M., Klein E. In vitro generation of cytotoxicity against autologous human tumour biopsy cells. Int J Cancer. 1978 May 15;21(5):588–593. doi: 10.1002/ijc.2910210508. [DOI] [PubMed] [Google Scholar]
  21. Zinkernagel R. M., Doherty P. C. Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system. Nature. 1974 Apr 19;248(5450):701–702. doi: 10.1038/248701a0. [DOI] [PubMed] [Google Scholar]
  22. de Vries J. E., Cornain S., Rumke P. Cytotoxity of non-T versus T-lymphocytes from melanoma patients and healthy donors on short- and long-term cultured melanoma cells,. Int J Cancer. 1974 Oct 15;14(4):427–434. doi: 10.1002/ijc.2910140402. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES