Figure 6.

Net I_sc responses to carbachol (a) and histamine (b), and the influence of DIDS on the Cl^– secretory response (c). Results are given for the whole group (all), and for the siblings belonging to CON_mild, CON_severe, and DISC pairs. For the CON_mild and CON_severe pairs, individuals were counted when there was a measurement value for only 1 sibling of a pair, while the mean of both siblings was included when there was a measurement for both siblings. For the individuals belonging to DISC pairs, data are compared between the clinically better (DISC_mild) and worse (DISC_severe) siblings. For each group of data, the interquartile range (IQR) is depicted by a rectangle, with the upper horizontal line indicating the 75th percentile, followed by the 50th percentile, and the lower horizontal line presenting the 25th percentile. The spread for the rest of the data points in the group is given by the upper and lower vertical lines initiating from the rectangle. Data points larger than 75th percentile + 1.5 IQR, and data points smaller than 25th percentile – 1.5 IQR are considered outliers and are indicated as individual data points. For groups with n < 6, single data points are given. Statistical comparisons were performed by the Mann-Whitney U test. *P ≤ 0.05 vs. CON_mild, ^‡0.001 < P < 0.01 vs. CON_mild, ^#P ≤ 0.05 vs. DISC_mild. CON+, CON_mild; CON–, CON_severe; DISC+, DISC_mild; DISC–, DISC_severe.