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. 2001 Dec 1;108(11):1667–1675. doi: 10.1172/JCI13202

Figure 7.

Figure 7

Antigen-specific immune response was enhanced in PPARγ+/– mice. (a) Proliferation of splenocytes from wild-type mice (open circles, +/+) and PPARγ+/– mice (filled circles, +/–), both of which were primed with OVA. Proliferation was measured by [3H]thymidine incorporation in the presence of various concentrations of OVA. Bars show the mean ± SD (n = 10 per group). The difference between the two groups was significant (*P < 0.01). (b) The level of Ab against OVA in sera from mice primed with OVA. Mice were bled 30 days after priming with OVA and assayed for the anti-OVA Ab level by ELISA. The mean Ab titers (± SD) of each group of ten mice are shown. The difference between the two groups was significant (*P < 0.01). (c) Proliferation against mBSA of splenocytes from mBSA-primed wild-type control mice (open circles, +/+) and PPARγ+/– mice (filled circles, +/–), respectively. Proliferation was measured by [3H]thymidine incorporation in the presence of various concentrations of mBSA. Bars show the mean ± SD (n = 10 per group).The difference between the two groups was significant (*P < 0.001). (d) Mice were bled 30 days after intra-articular challenge with mBSA and assayed for the anti-mBSA Ab level by ELISA. The mean Ab titers (± SD) of each group of the total ten mice are shown. The statistical difference between PPARγ+/– and PPARγ+/+ littermates derived from the same litter were significant (*P < 0.01).