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. 1980 Feb;41(2):204–208. doi: 10.1038/bjc.1980.31

Prostaglandin-like material extracted from squamous carcinomas of the head and neck.

A Bennett, R L Carter, I F Stamford, N S Tanner
PMCID: PMC2010208  PMID: 7370160

Abstract

Tumour-associated prostaglandin-like material, assessed by bioassay, has been examined in 37 patients with primary and metastatic squamous carcinomas of the head and neck, previously treated by radiotherapy and chemotherapy followed by radical surgery. High amounts of prostaglandin-like material were extracted from tumours excised within 3 months of radiotherapy and chemotherapy. These amounts correlated with necrosis, inflammation and fibrosis, but not with tumour site, size or degree of differentiation. Most of the prostaglandins formed by these treated tumours thus seem to be associated with host stromal and inflammatory cells, rather than the neoplastic cells. The possible roles of prostaglandins in facilitating the spread of squamous carcinomas are discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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