TABLE 5.
M. tuberculosis CFU numbers in various monkeys at necropsya
| Monkey | Category | Granulomab
|
Right lower or middle lungc | Left upper lungc | Left hilar lymph nodec | Right hilar lymph nodec | |
|---|---|---|---|---|---|---|---|
| no. 1 | no. 2 | ||||||
| 72-00 | Active-chronic; advanced disease at necropsy | 6.2 × 104 | 2.2 × 106 | 2 × 104 | 8.3 × 103 | 8.4 × 102 | 1.2 × 104 |
| 112-01 | Latent, then severe disease | 1.9 × 107 | 2.8 × 105 | 3.7 × 104 | 4.4 × 105 | NDd | 4.4 × 106 |
| 152-00 | Active-chronic then resolving | 4.8 × 103 | 0 (all others) | 2.6 × 103 | 0 | 0 | 0 |
| 146-00 | Latent | 1.1 × 103 | ND | 0 | 0 | 0 | 1.5 × 103 |
Tissue was homogenized in saline, dilutions were plated on 7H10 plates, and plates were read after 21 to 28 days of incubation at 37°C with 5% CO2. Data for representative monkeys of each category are shown.
CFU in entire granuloma; 1 and 2 refer two different granulomas.
CFU per gram of tissue.
ND, not done.