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Nonsense mutation in DNA-PKcs gene in SCID mice. The dark box indicates the ORF (1-4128). Only the mutated region is indicated above. nt. and a.a. indicate the nucleotide sequence and amino acid sequence, respectively. The replaced nucleotides and amino acid residues are shown in boldface type. The one-letter symbols are used to specify amino acids. AluI indicates the recognition sequence of restriction enzyme AluI.
