TABLE 1.
IL-18 KO mice have an increased granulocyte influx into the peritoneal fluid during peritonitisa
| Cell type | Cell counts in peritoneal fluid at time:
|
|||||
|---|---|---|---|---|---|---|
| 0 h
|
6 h
|
20 h
|
||||
| WT (104/ml) | KO (104/ml) | WT (106/ml) | KO (106/ml) | WT (106/ml) | KO (106/ml) | |
| Total cells | 15 ± 0.1 | 14.2 ± 0.2 | 7.6 ± 1.4 | 11.2 ± 2.4* | 2.2 ± 0.2 | 5.2 ± 0.9* |
| Neutrophils | 0.9 ± 0.1 | 1.1 ± 0.2 | 5.8 ± 1.5 | 7.9 ± 1.4* | 1.1 ± 0.7 | 3.9 ± 0.6* |
| Macrophages | 14.0 ± 0.6 | 13.1 ± 0.7 | 1.3 ± 0.6 | 2.6 ± 0.7 | 0.6 ± 0.6 | 1.1 ± 0.2 |
| Other | 0.0 ± 0.3 | 0.0 ± 0.2 | 0.5 ± 0.3 | 0.7 ± 0.3 | 0.5 ± 0.1 | 0.2 ± 0.1 |
a
Mice were sacrificed at 0, 6, and 20 h after i.p. administration of 104 CFU of E. coli to obtain peritoneal lavage fluid. Data are mean ± standard error of the mean. Note that cell counts are given as 104/ml at t = 0 and as 106/ml at t = 6 and 20 h. Each group consisted of eight mice for each time point, except the t = 0 group (five mice). *, P < 0.05 versus WT mice.