TABLE 1.
Spearman rank correlation coefficients for log-transformed data describing the association between IgG1 or IgM responses to S. mansoni crude adult worm antigen (SWA), SEA, and CERC as well as KLH measured by ELISA and specific IgG1 or IgM responses against the neoglycan epitopes FLDN, LDN-DF, and LDNF measured by SPR
Epitope | Response | Value for antigen and cohorta
|
|||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SWA
|
SEA
|
CERC
|
KLH
|
||||||||||
I | II | III | I | II | III | I | II | III | I | II | III | ||
FLDN | IgG1 | NS | NS | NS | 0.43*** | 0.36** | 0.31* | 0.53*** | 0.28* | NS | 0.73*** | 0.39** | 0.384** |
IgM | NS | NS | NS | NS | NS | NS | NS | NS | NS | NS | NS | NS | |
LDN-DF | IgG1 | NS | NS | NS | 0.52*** | 0.33** | 0.20* | 0.56*** | 0.26** | 0.17* | 0.56*** | NS | NS |
IgM | NS | NS | NS | 0.36* | NS | 0.37*** | 0.48** | NS | NS | NS | NS | 0.412*** | |
LDNF | IgG1 | NS | NS | NS | NS | NS | NS | NS | NS | NS | NS | NS | NS |
IgM | NS | NS | NS | 0.30*** | 0.25** | 0.35*** | NS | NS | 0.2* | NS | NS | 0.26** |
Cohorts: I, immigrant cohort (n = 184) sampled within 1 year of first exposure to S. mansoni; II, same cohort sampled again 2 years later; III, resident cohort (n = 235). Significance: *, P < 0.05; **, 0.001 < P < 0.05; ***, P < 0.001; NS, not significant.