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Effect of OPG treatment on severity of joint destruction
| Condition | No. of mice | No. of mice with bone destructiona |
|---|---|---|
| No infection | 5 | 0 |
| S. pyogenes JRS4 infection | ||
| Untreated | 10 | 7 |
| Treated with OPGb | 5 | 1 |
Bone destruction index greater than 2. P < 0.05 versus untreated. The results for no infection versus treated with OPG were not significant (Mann-Whitney U test).
OPG (1 mg/kg/day) was administered subcutaneously daily from day 3 to day 9 after GAS infection.
