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Effects of C4-HSL and 3-oxo-C12-HSL on MIP-2 and MCP-1 production in BM-derived macrophages. BM-derived macrophages were incubated with or without increasing concentrations of Pseudomonas C4-HSL (closed columns) or 3-oxo-C12-HSL (open columns) for 18 h. Levels of MIP-2 (a) and MCP-1 (b) in culture supernatants were then determined by ELISA (n = 5). *, P < 0.05 compared with a nontreated control group.
