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. 2003 Oct;71(10):5541–5548. doi: 10.1128/IAI.71.10.5541-5548.2003

FIG. 6.

FIG. 6.

Pneumococcal LTA and LTA-1 require CD14, TLR1, and TLR2 for TNF-α production in human PBMCs. Human PBMCs were treated with anti-TLR1, anti-TLR2, anti-TLR4, or anti-CD14 antibody for 40 min prior to stimulation with 30 μg of pneumococcal LTA and its variants per ml for 20 h. The levels of TNF-α were determined by sandwich ELISA. Data are expressed as means ± standard deviations. *, **, and ***, P < 0.05, <0.01, and <0.001, respectively. Statistical significance between groups was evaluated by analysis of variance.