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. 1982 Jan;45(1):10–16. doi: 10.1038/bjc.1982.2

Cellular repair factors influencing radiocurability of human malignant tumours.

R R Weichselbaum, A Schmit, J B Little
PMCID: PMC2010946  PMID: 7059452

Abstract

We have studied the repair of X-ray-induced, potentially lethal damage (PLD) in 9 human tumour lines derived from tumours of varying radiocurability. Cells derived from 3 tumours considered non-radiocurable (1 osteosarcoma, 2 melanoma) repaired significantly more X-ray PLD than cells from 3 tumours considered radiocurable (2 breast, 1 neuroblastoma). The remaining tumour lines were intermediate in their ability for repair, and included cells from another osteosarcoma, a hypernephroma and a glioblastoma. We conclude that the repair of X-ray PLD may be an important cellular determinant of clinical radiocurability.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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