TABLE 1.

Mice rendered genetically deficient in CD1d-restricted NKT cells exhibit a spectrum of susceptibility to infectious disease

Finding	αGalCer enhances host resistance in +/+ mice	αGalCer not tested
CD1d−/− or Jα281−/− mice have more-severe disease than do +/+ mice	P. aeruginosa, C. neoformans, HSV, ECMV-Db	B. burgdorferi, Plasmodium-infected erythrocytes,aL. major, RSVa
CD1d−/− or Jα281−/− mice have disease similar to +/+ mice	M. tuberculosis, Plasmodium sporozoite, T. cruzic
CD1d−/− or Jα281−/− mice have less-severe disease than do +/+ mice	Coxsackievirus B3,b RSVa	S. choleraesuis, L. monocytogenes,dPlasmodium-infected erythrocytesa

^aThe phenotype depends on the mouse strain.

^bA role for diverse CD1d-restricted T cells is suggested by the data.

^cThe phenotype depends upon virulence of pathogen.

^dOnly anti-CD1d antibody blockade was tested.