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. 2003 Oct;71(10):6035–6044. doi: 10.1128/IAI.71.10.6035-6044.2003

TABLE 2.

Relative expression ratios of 9HTEo− cell genes regulated by P. aeruginosa infection

Class and gene designation Full gene name Accession no.a Function Relative expression ratio of P. aeruginosa strain:
Pb
PA103 exoT exoU exoTU pscJ pilA
Class A: type III independently activated genes
    VEGFA Vascular endothelial growth factor A n91060 Proinflammatory 8.04 4.98 5.65 5.72 5.69 6.17 0.001
    VEGFA Vascular endothelial growth factor A aa126903 Proinflammatory 4.9 4.46 2.76 2.65 3.86 3.37 0.001
    IGFBP3 Insulin-like growth factor binding protein 3 n24118 Proinflammatory 2.58 2.02 2.71 2.58 3.65 2.91 0.1
    ADM Adrenomedullin w19284 Proinflammatory, antimicrobial 6.43 2.15 9.62 4.97 5.76 5.43 0.1
    FSTL3 Follistatin-like 3 n75101 Proinflammatory 2.13 1.78 1.63 2.4 2.18 1.59 0.04
    IRS2 Insulin receptor substrate-2 aa035325 Signal regulator 3.41 1.47 2 2.31 2.57 2.05 0.01
    ANKRD3, DIK Dual-specificity Ser/Thr/Tyr kinase 3 (dik gene) w37332 Signal regulator 3.71 2.63 4.66 3.49 4.41 3.59 0.06
    STC1S Stanniocalcin 1 r48681 Autocrine signal 20.37 4.75 11.75 11.22 13.66 6.23 0.08
    SRA1 Steroid receptor RNA activator r50254 Transcription regulator 7.34 4.34 6.49 6.57 8.44 9.68 0.08
    NFIL3 Nuclear factor regulated by IL-3 w67706 Transcription activator 5.59 4.69 4.85 4.74 7.56 3.99 0.03
    MT1E Metallothionein 1E h93127 Oxidant protection 4.64 1.61 4.05 2.06 4.68 3.42 0.06
    MT1E Metallothionein 1E h52525 Oxidant protection 3.47 1.43 3.87 2.49 4.4 4.06 0.17
    MT1G Metallothionein 1G w78010 Oxidant protection 4.3 1.37 3.08 3.25 4.1 3.71 0.15
    MT1G Metallothionein 1G h57208 Oxidant protection 2.9 1.55 2.7 2.52 4.22 4.13 0.2
    MT2A Metallothionein 2A h91612 Oxidant protection 4.22 1.54 2.95 2.91 3.81 4.08 0.2
    Oatprp1 Organic anion transporter member 12 h84604 Membrane transport 3.05 2.33 1.85 5.51 2.7 3.12 0.2
    SLC2A1 Solute carrier protein 2 w58375 Membrane transport 2.96 3.66 2.35 3.18 2.93 2.66 0.02
    ADFP Adipose differentiation-related protein (adipophilin) w20444 Membrane protein, inducible 3.42 2.51 1.94 1.69 2.87 2.01 0.2
    U2AF65 U2 small nuclear ribonucleoprotein auxiliary factor aa053859 mRNA processing 2.73 1.64 1.94 1.89 1.42 1.45 0.01
    RNA pol I (16 kDa) RNA polymerase I 16-kDa subunit n71041 mRNA processing 2.28 1.72 1.58 1.83 2.01 1.63 0.2
    PCR17 Rab GTPase-activating protein aa047487 Signal regulator 2.25 0.94 2.07 2.53 1.91 1.7 0.2
    SYN2 Syndecan 2 aa156696 Wound repair 3.1 2.43 3.83 3.37 3.68 2.6 0.1
    EHD4 EH domain containing 4 n94535 2.28 1.48 2.52 1.29 2.15 2.53 0.2
    EST Chromosome 14q24.3, BAC 201F1 h91088 3.52 3.34 3.21 2.9 3.09 2.89 0.01
    EST Hypothetical protein FLJ21616 r98518 3.03 1.33 2.54 2.33 3.33 3.68 0.07
    EST No homology n68160 3.01 2.68 2.69 3.33 1.94 1.96 0.17
    EST Hypothetical protein DKFZp566J091 aa040473 2.91 1.9 2.09 2.15 2.19 2.26 0.02
Class B type III independently repressed genes
    DUSP6 Dual-specificity phosphatase 6 t65557 Signal regulator 0.65 0.39 0.46 0.59 0.56 0.54 0.17
    TRXIP Thioredoxin-interacting protein n71361 Oxidant protection 0.24 0.26 0.15 0.13 0.15 0.15 0.001
    EST KIAA1515 protein r40307 0.24 0.15 0.079 0.073 0.13 0.08 0.1
    EST Chromosome 11q, clone:RP11-687M24 h09816 0.35 0.7 0.49 0.66 0.53 0.64 0.003
    EST Hypothetical protein (HSPC210) h72619 0.43 0.06 0.43 0.12 0.17 0.16 0.1
Class C: exoU-dependent activated genes
    DUSP1 Dual-specificity phosphatase 1 r79387 Signal regulator 50.19 13.76 3.97 3.15 2.16 2.49 0.09
    DUSP1 Dual-specificity phosphatase 1 h87493 Signal regulator 11.43 11.52 3.86 6.25 2.18 2.61 0.005
    DUSP1 Dual-specificity phosphatase 1 h29136 Signal regulator 15.85 5.48 4.22 3.85 1.91 2.12 0.001
    DUSP1 Dual-specificity phosphatase 1 h01773 Signal regulator 14.36 8.64 4.45 6 2.02 2.89 0.03
    KNSL5 Kinesin-like 5 aa043507 Signal regulator 7.07 6.34 1.98 2.05 3.54 2.32 0.003
    RhoB Transforming protein RhoB (ras homolog) w67471 Signal regulator 7.3 0.668 2.85 2.06 2.46 1.41 0.1/PICK>
    RhoB Transforming protein RhoB (ras homolog) r32081 Signal regulator 4.54 4.82 2.01 2.78 2.32 2.22 0.07
    FOS v-fos FBJ murine osteosarcoma viral oncogene homolog aa019816 Transcription activator 20.8 3.1 2.72 4.01 4.3 1.62 0.1
    MYC v-myc proto-oncogene protein w87861 Transcription activator 10.37 5.66 3.42 2.44 5.95 3.69 0.1
    MYC v-myc proto-oncogene protein h43827 Transcription activator 7.73 10 2.99 3.28 2.63 3.26 0.02
    NR4A1/nur77 Nuclear receptor subfamily 4, grpA, murine nur77 homolog n64388 Transcription activator 5.37 1.6 1.26 2.02 1.56 1.04 0.2
    BPTF Bromodomain transcription factor h02279 Transcription activator 4.04 3.01 1.96 2.95 1.5 1.68 0.03
    TTP Tristetraproline aa054080 Transcription activator mRNA stability 3.7 1.51 2.02 2.78 1.18 1.6 0.1
    TCF8/ Transcription factor 8 aa150750 Transcription repressor 16.46 5.23 3 2.99 1.78 1.49 0.02
    TCF8 Transcription factor 8 r43502 Transcription repressor 4.44 3.17 2.07 2.43 1.34 1.61 0.03
    PLAUR Urokinase type plasminogen activator receptor t75241 Protease regulator 4.85 1.4 0.69 0.9 0.51 0.61 0.1
    EST Chromosome 14, BAC R-156E22 r85513 20.4 20.8 2.79 2.9 2.16 1.62 0.004
    EST Similar to hypothetical protein FLJ11328 aa044730 6.3 6.98 2.22 2.46 2.9 2.41 0.1
    EST No homology h87673 4.97 3.65 1.55 1.71 1.14 1.74 0.09
    EST Hypothetical protein FLJ22182 aa156747 4.47 5.49 2.02 1.87 2.2 2 0.05
Class D: type III-dependent activated genes
    MCP1/SCYA2 Monocyte chemotactic protein 1 aa024753 Proinflammatory 1.93 2.66 3.63 3.78 0.72 1.31 0.1
    MCP1/SCYA2 Monocyte chemotactic protein 1 r75975 Proinflammatory 1.12 2.32 2.44 2.88 0.7 0.82 0.1
    TIEG TGF-early inducible gene aa045730 Transcription activator 2.62 2.21 1.87 1.97 1.35 1.21 0.002
a

GenBank accession number.

b

As determined by Student t test analysis.