TABLE 1.
Organism | Antimicrobial agent | France
|
Germany
|
Italy
|
Spain
|
Canada
|
United States
|
||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of isolates | % Susceptible | No. of isolates | % Susceptible | No. of isolates | % Susceptible | No. of isolates | % Susceptible | No. of isolates | % Susceptible | No. of isolates | % Susceptible | ||
E. coli | Amikacin | 75,385 | 99.4 | 25,704 | 99.8 | 22,884 | 99.2 | 17,232 | 99.8 | 18,024 | 99.6 | 74,220 | 99.5 |
Amoxicillin-clavulanate | 83,690 | 69.9 | 6,205 | 78.8 | 21,667 | 80.6 | 24,101 | 85.8 | 19,286 | 79.6 | 45,434 | 81.2 | |
Ampicillin | 33,822 | 53.6 | 21,339 | 58.3 | 23,263 | 56.5 | 19,705 | 39.2 | 52,354 | 64.6 | 135,321 | 57.9 | |
Cefepime | 30,427 | 99.6 | 16,758 | 99.2 | 8,955 | 99.2 | 12,137 | 98.4 | 1,636 | 99.3 | 54,041 | 99.1 | |
Cefotaxime | 82,657 | 99.6 | 44,149 | 99.1 | 19,542 | 97.1 | 22,991 | 98.2 | 18,927 | 97.0 | 54,268 | 98.3 | |
Cefpirome | 14,045 | 99.6 | NAb | NA | NA | NA | NA | NA | NA | NA | NA | NA | |
Ceftazidime | 77,457 | 99.1 | 22,800 | 98.9 | 23,216 | 96.5 | 21,303 | 98.1 | 39,585 | 98.7 | 81,300 | 97.0 | |
Ceftriaxone | 7,278 | 99.5 | 3,193 | 99.8 | 10,410 | 96.7 | 793 | 97.4 | 36,293 | 98.6 | 97,940 | 98.5 | |
Cefuroxime | 11,384 | 92.8 | 35,157 | 91.9 | 7,643 | 87.0 | 14,507 | 91.9 | 20,340 | 92.9 | 54,084 | 91.7 | |
Ciprofloxacin | 64,199 | 94.0 | 36,898 | 88.4 | 24,201 | 84.7 | 23,473 | 80.5 | 45,854 | 93.2 | 110,811 | 92.4 | |
Gentamicin | 84,261 | 96.7 | 41,428 | 95.2 | 26,319 | 92.8 | 23,967 | 91.1 | 46,778 | 94.8 | 135,528 | 95.0 | |
Imipenem | 75,852 | 100 | 37,172 | 100 | 20,230 | 100 | 13,254 | 100 | 32,838 | 100 | 87,433 | 100 | |
Levofloxacin | NA | NA | 16,582 | 89.8 | 2,269 | 85.2 | 169 | 75.2 | 5,974 | 90.3 | 100,223 | 91.6 | |
Piperacillin-tazobactam | 52,063 | 97.0 | 42,439 | 96.5 | 12,857 | 96.8 | 10,674 | 96.5 | 37,473 | 96.6 | 70,784 | 95.3 | |
TMP-SMX | 82,535 | 78.6 | 42,715 | 73.2 | 25,640 | 74.4 | 24,379 | 67.6 | 52,224 | 83.5 | 135,210 | 80.7 | |
K. pneumoniae | Amikacin | 7,704 | 96.9 | 5,915 | 99.3 | 4,888 | 94.2 | 2,290 | 98.9 | 5,663 | 99.6 | 28,688 | 98.4 |
Amoxicillin-clavulanate | 8,382 | 82.6 | 1,130 | 76.8 | 4,658 | 79.5 | 3,158 | 87.0 | 5,950 | 93.1 | 16,734 | 90.1 | |
Ampicillin | 3,249 | 0.6 | 4,424 | 0.9 | 4,126 | 1.4 | 2,639 | 0.9 | 14,605 | 1.0 | 46,943 | 1.3 | |
Cefepime | 3,409 | 95.8 | 3,925 | 95.1 | 1,629 | 96.6 | 1,710 | 87.0 | 574 | 98.8 | 23,462 | 96.7 | |
Cefotaxime | 8,378 | 96.1 | 10,088 | 93.8 | 4,135 | 90.4 | 3,052 | 91.3 | 5,919 | 98.3 | 21,812 | 93.6 | |
Cefpirome | 1,360 | 92.8 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | |
Ceftazidime | 8,105 | 94.4 | 5,299 | 92.4 | 5,204 | 83.9 | 2,823 | 90.9 | 11,573 | 98.4 | 33,261 | 90.9 | |
Ceftriaxone | 476 | 90.6 | 461 | 98.7 | 2,695 | 86.6 | 119 | 94.1 | 9,902 | 98.7 | 37,426 | 94.5 | |
Cefuroxime | 1,107 | 81.4 | 8,524 | 86.3 | 1,499 | 72.3 | 1,858 | 89.1 | 6,672 | 90.0 | 20,816 | 81.8 | |
Ciprofloxacin | 6,889 | 92.7 | 8,722 | 87.2 | 5,339 | 91.6 | 3,032 | 95.5 | 13,276 | 94.8 | 40,605 | 92.1 | |
Gentamicin | 8,396 | 97.2 | 9,631 | 93.7 | 5,393 | 90.1 | 3,177 | 89.1 | 13,837 | 97.5 | 49,694 | 94.1 | |
Imipenem | 8,007 | 100 | 9,265 | 100 | 4,772 | 100 | 1,809 | 100 | 9,430 | 100 | 35,247 | 100 | |
Levofloxacin | NA | NA | 4,065 | 93.1 | 588 | 92.0 | NA | NA | 2,153 | 94.8 | 37,636 | 92.9 | |
Piperacillin-tazobactam | 5,626 | 92.9 | 9,893 | 86.2 | 2,387 | 89.7 | 1,362 | 89.3 | 10,959 | 93.9 | 30,227 | 89.5 | |
TMP-SMX | 8,140 | 87.5 | 9,890 | 83.3 | 5,174 | 82.9 | 3,193 | 85.5 | 14,726 | 92.5 | 49,187 | 89.1 | |
K. oxytoca | Amikacin | 3,624 | 98.4 | 2,990 | 99.8 | 795 | 98.0 | 840 | 99.6 | 1,475 | 99.8 | 4,710 | 99.2 |
Amoxicillin-clavulanate | 3,887 | 82.7 | 444 | 79.1 | 727 | 83.9 | 1,216 | 84.5 | 1,447 | 90.5 | 2,560 | 83.5 | |
Ampicillin | 1,707 | 0.7 | 2,071 | 3.7 | 882 | 3.5 | 933 | 2.1 | 3,598 | 0.9 | 7,624 | 1.2 | |
Cefepime | 1,642 | 97.1 | 1,815 | 94.0 | 602 | 98.5 | 563 | 94.1 | 110 | 99.1 | 3,955 | 96.5 | |
Cefotaxime | 3,879 | 97.6 | 4,979 | 92.7 | 623 | 95.5 | 1,170 | 96.2 | 1,620 | 96.7 | 3,933 | 93.1 | |
Cefpirome | 748 | 96.4 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | |
Ceftazidime | 3,735 | 98.7 | 2,555 | 94.5 | 929 | 88.7 | 1,160 | 96.8 | 2,814 | 98.1 | 5,790 | 92.4 | |
Ceftriaxone | 291 | 83.5 | 327 | 99.7 | 518 | 88.6 | NA | NA | 2,430 | 97.0 | 6,133 | 90.6 | |
Cefuroxime | 506 | 80.6 | 4,186 | 80.4 | 512 | 75.6 | 624 | 84.1 | 1,791 | 89.1 | 4,080 | 78.6 | |
Ciprofloxacin | 3,298 | 92.5 | 4,122 | 88.1 | 984 | 93.6 | 1,195 | 94.2 | 3,277 | 97.3 | 6,902 | 91.9 | |
Gentamicin | 3,892 | 96.4 | 4,818 | 97.8 | 993 | 92.6 | 1,215 | 97.9 | 3,444 | 97.0 | 8,162 | 92.4 | |
Imipenem | 3,642 | 100 | 4,562 | 100 | 837 | 100 | 615 | 100 | 2,315 | 100 | 5,932 | 100 | |
Levofloxacin | NA | NA | 1,802 | 92.8 | 284 | 95.8 | NA | NA | 492 | 98.4 | 5,751 | 93.1 | |
Piperacillin-tazobactam | 2,688 | 87.2 | 4,856 | 80.6 | 766 | 88.0 | 525 | 89.5 | 2,716 | 93.6 | 4,964 | 86.2 | |
TMP-SMX | 3,769 | 92.1 | 4,799 | 88.9 | 919 | 90.4 | 1,218 | 91.5 | 3,637 | 95.7 | 8,015 | 91.0 | |
E. cloacae | Amikacin | 6,230 | 97.9 | 3,838 | 99.3 | 2,314 | 96.6 | 1,935 | 99.6 | 3,197 | 99.6 | 15,154 | 98.3 |
Amoxicillin-clavulanate | 6,410 | 3.4 | 814 | 5.4 | 2,106 | 4.8 | 2,509 | 1.9 | 2,742 | 4.4 | 7,442 | 3.5 | |
Ampicillin | 2,470 | 2.8 | 3,242 | 9.0 | 1,941 | 7.1 | 1,976 | 4.3 | 6,823 | 1.6 | 22,307 | 2.7 | |
Cefepime | 3,335 | 91.7 | 2,746 | 96.5 | 1,245 | 93.0 | 1,954 | 93.8 | 298 | 97.3 | 13,595 | 92.2 | |
Cefotaxime | 6,463 | 71.3 | 6,777 | 72.8 | 2,145 | 56.8 | 1,866 | 78.8 | 3,254 | 75.7 | 13,373 | 63.8 | |
Cefpirome | 1,241 | 79.5 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | |
Ceftazidime | 6,359 | 70.6 | 4,096 | 68.5 | 2,732 | 57.5 | 1,846 | 74.0 | 5,427 | 79.3 | 18,661 | 64.9 | |
Ceftriaxone | 593 | 52.8 | 446 | 86.8 | 1,584 | 61.1 | 88 | 72.7 | 4,821 | 78.4 | 18,879 | 66.9 | |
Cefuroxime | 790 | 32.2 | 5,553 | 13.3 | 979 | 24.2 | 1,519 | 26.3 | 3,775 | 40.7 | 11,373 | 32.7 | |
Ciprofloxacin | 5,657 | 85.7 | 5,754 | 90.5 | 2,774 | 77.7 | 2,479 | 96.0 | 6,486 | 93.6 | 20,019 | 87.3 | |
Gentamicin | 6,456 | 89.8 | 6,449 | 95.5 | 2,797 | 77.1 | 2,514 | 99.0 | 6,652 | 96.2 | 24,286 | 89.5 | |
Imipenem | 6,273 | 100 | 6,268 | 100 | 2,569 | 100 | 1,640 | 100 | 4,660 | 100 | 19,108 | 100 | |
Levofloxacin | NA | NA | 2,806 | 92.3 | 620 | 68.6 | NA | NA | 1,098 | 92.3 | 18,087 | 88.7 | |
Piperacillin-tazobactam | 5,006 | 73.6 | 6,682 | 73.4 | 1,475 | 64.3 | 1,302 | 74.3 | 5,427 | 77.2 | 15,129 | 70.0 | |
TMP-SMX | 6,202 | 90.7 | 6,571 | 93.0 | 2,623 | 86.3 | 2,527 | 95.0 | 6,890 | 93.2 | 23,724 | 86.9 | |
E. aerogenes | Amikacin | 3,751 | 71.8 | 782 | 99.9 | 1,241 | 89.8 | 503 | 98.6 | 805 | 99.6 | 6,088 | 98.5 |
Amoxicillin-clavulanate | 3,996 | 2.8 | 198 | 1.5 | 1,164 | 6.4 | 622 | 4.0 | 771 | 7.1 | 3,408 | 5.7 | |
Ampicillin | 1,727 | 0.4 | 589 | 2.0 | 1,013 | 2.9 | 531 | 3.8 | 1,820 | 2.1 | 9,814 | 2.9 | |
Cefepime | 2,327 | 85.3 | 499 | 98.0 | 556 | 94.1 | 519 | 95.6 | NA | NA | 5,441 | 95.8 | |
Cefotaxime | 4,029 | 48.2 | 1,291 | 79.0 | 1,024 | 58.6 | 511 | 74.2 | 816 | 80.9 | 5,335 | 72.2 | |
Cefpirome | 1,131 | 74.1 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA/PICK> | |
Ceftazidime | 4,051 | 31.2 | 705 | 59.9 | 1,362 | 42.3 | 490 | 67.1 | 1,528 | 83.0 | 7,853 | 68.9 | |
Ceftriaxone | 404 | 32.7 | 103 | 58.3 | 780 | 52.4 | NA | NA | 1,310 | 85.3 | 8,138 | 73.4 | |
Cefuroxime | 689 | 16.4 | 974 | 57.6 | 456 | 27.0 | 437 | 42.8 | 953 | 66.4 | 4,853 | 55.9 | |
Ciprofloxacin | 3,703 | 34.2 | 1,116 | 91.9 | 1,380 | 62.1 | 605 | 91.1 | 1,744 | 94.3 | 8,655 | 93.4 | |
Gentamicin | 4,028 | 95.3 | 1,178 | 98.3 | 1,382 | 87.6 | 636 | 96.5 | 1,798 | 99.1 | 10,564 | 95.5 | |
Imipenem | 4,003 | 100 | 1,201 | 100 | 1,255 | 100 | 476 | 100 | 1,300 | 100 | 7,949 | 100 | |
Levofloxacin | NA | NA | 568 | 94.9 | 269 | 57.3 | NA | NA | 272 | 92.7 | 7,875 | 94.4 | |
Piperacillin-tazobactam | 2,995 | 45.5 | 1,277 | 69.5 | 758 | 59.5 | 377 | 67.4 | 1,480 | 81.4 | 6,333 | 72.8 | |
TMP-SMX | 3,910 | 52.7 | 1,265 | 94.2 | 1,316 | 61.9 | 637 | 92.0 | 1,847 | 97.0 | 10,325 | 95.7 | |
P. mirabilis | Amikacin | 11,063 | 97.5 | 4,979 | 99.8 | 4,728 | 99.0 | 2,804 | 99.5 | 2,476 | 99.7 | 13,935 | 99.3 |
Amoxicillin-clavulanate | 11,920 | 77.9 | 1,157 | 96.7 | 4,457 | 83.8 | 3,906 | 94.8 | 3,240 | 93.9 | 6,978 | 96.5 | |
Ampicillin | 4,608 | 60.5 | 3,876 | 69.6 | 4,200 | 42.6 | 3,214 | 60.9 | 7,070 | 82.2 | 23,265 | 83.5 | |
Cefepime | 4,625 | 98.9 | 3,368 | 99.6 | 1,594 | 94.2 | 1,995 | 99.0 | 242 | 96.7 | 9,735 | 98.3 | |
Cefotaxime | 11,860 | 99.1 | 8,504 | 99.3 | 4,069 | 71.9 | 3,762 | 99.7 | 2,614 | 99.2 | 10,232 | 99.4 | |
Cefpirome | 1,874 | 97.8 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | |
Ceftazidime | 11,298 | 98.9 | 4,624 | 99.1 | 4,811 | 87.8 | 3,464 | 99.4 | 5,659 | 99.1 | 14,604 | 98.4 | |
Ceftriaxone | 635 | 99.7 | 568 | 98.8 | 1,846 | 81.0 | 91 | 98.9 | 5,141 | 99.5 | 17,912 | 99.5 | |
Cefuroxime | 1,488 | 95.2 | 6,893 | 97.6 | 1,358 | 57.2 | 2,264 | 98.1 | 2,800 | 98.0 | 9,246 | 97.2 | |
Ciprofloxacin | 9,866 | 85.8 | 7,319 | 89.1 | 4,963 | 73.2 | 3,833 | 89.3 | 6,349 | 92.4 | 18,586 | 84.6 | |
Gentamicin | 12,006 | 92.7 | 7,930 | 92.6 | 5,007 | 64.9 | 3,921 | 89.7 | 6,653 | 93.5 | 23,429 | 91.4 | |
Imipenem | 9,739 | 99.9 | 7,168 | 100 | 4,197 | 100 | 2,057 | 100 | 4,661 | 100 | 15,453 | 100 | |
Levofloxacin | NA | NA | 3,336 | 93.1 | 390 | 77.2 | NA | NA | 929 | 98.5 | 18,137 | 85.5 | |
Piperacillin-tazobactam | 7,840 | 99.2 | 8,456 | 98.8 | 2,077 | 98.2 | 1,739 | 99.4 | 5,344 | 97.6 | 13,618 | 97.7 | |
TMP-SMX | 11,595 | 80.7 | 8,040 | 71.8 | 4,854 | 54.9 | 3,952 | 63.7 | 7,061 | 82.0 | 23,319 | 83.6 | |
S. marcescens | Amikacin | 2,180 | 90.8 | 1,768 | 98.8 | 1,087 | 97.4 | 705 | 98.0 | 1,775 | 99.1 | 8,296 | 98.2 |
Amoxicillin-clavulanate | 2,229 | 2.9 | 447 | 2.7 | 981 | 2.2 | 908 | 5.7 | 1,661 | 2.9 | 3,757 | 1.6 | |
Ampicillin | 906 | 2.0 | 1,270 | 7.4 | 858 | 7.0 | 765 | 8.2 | 3,612 | 11.1 | 12,611 | 5.9 | |
Cefepime | 1,274 | 98.3 | 1,212 | 98.6 | 610 | 98.2 | 754 | 97.6 | 133 | 97.7 | 7,313 | 96.8 | |
Cefotaxime | 2,252 | 81.0 | 2,827 | 91.2 | 930 | 85.7 | 736 | 92.1 | 1,782 | 93.5 | 7,194 | 85.5 | |
Cefpirome | 526 | 97.2 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | |
Ceftazidime | 2,214 | 95.8 | 1,808 | 92.1 | 1,279 | 87.7 | 673 | 94.5 | 3,064 | 96.3 | 10,480 | 89.4 | |
Ceftriaxone | 322 | 65.5 | 316 | 53.8 | 800 | 85.3 | NA | NA | 2,594 | 95.7 | 10,511 | 90.6 | |
Cefuroxime | 296 | 1.4 | 2,208 | 0.6 | 453 | 1.8 | 540 | 1.9 | 1,930 | 1.9 | 6,228 | 0.7 | |
Ciprofloxacin | 2,034 | 76.3 | 2,659 | 66.2 | 1,293 | 88.5 | 915 | 90.7 | 3,559 | 85.4 | 11,138 | 89.5 | |
Gentamicin | 2,269 | 90.0 | 2,472 | 90.8 | 1,294 | 96.0 | 928 | 97.1 | 3,579 | 94.0 | 13,443 | 94.2 | |
Imipenem | 2,194 | 100 | 2,794 | 100 | 1,252 | 100 | 614 | 100 | 2,514 | 100 | 10,591 | 100 | |
Levofloxacin | NA | NA | 1,288 | 83.2 | 298 | 96.3 | NA | NA | 563 | 92.2 | 10,233 | 93.5 | |
Piperacillin-tazobactam | 1,733 | 81.5 | 2,897 | 85.7 | 726 | 94.1 | 503 | 91.9 | 3,125 | 92.8 | 9,245 | 87.8 | |
TMP-SMX | 2,105 | 80.5 | 2,715 | 83.7 | 1,130 | 87.4 | 930 | 96.0 | 3,671 | 92.8 | 13,192 | 95.5 | |
M. morganii | Amikacin | 2,975 | 98.8 | 1,061 | 99.6 | 1,098 | 98.7 | 1,041 | 99.6 | 666 | 99.7 | 3,090 | 99.0 |
Amoxicillin-clavulanate | 3,128 | 1.4 | 254 | 3.9 | 1,015 | 2.9 | 1,356 | 1.3 | 738 | 1.9 | 1,515 | 3.8 | |
Ampicillin | 1,092 | 0.5 | 871 | 1.3 | 916 | 1.8 | 1,120 | 0.8 | 1,659 | 1.7 | 4,897 | 3.4 | |
Cefepime | 1,452 | 98.1 | 790 | 96.3 | 367 | 99.2 | 1,071 | 97.7 | 52 | 100 | 2,555 | 97.5 | |
Cefotaxime | 3,154 | 87.8 | 1,930 | 89.3 | 903 | 69.3 | 996 | 89.8 | 717 | 87.3 | 2,441 | 81.8 | |
Cefpirome | 560 | 93.8 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | |
Ceftazidime | 3,051 | 85.5 | 1,017 | 86.1 | 1,160 | 76.6 | 975 | 85.4 | 1,318 | 83.5 | 3,559 | 75.7 | |
Ceftriaxone | 220 | 90.5 | 90 | 95.6 | 558 | 86.9 | 64 | 96.9 | 1,224 | 96.6 | 3,981 | 91.9 | |
Cefuroxime | 437 | 8.0 | 1,627 | 4.1 | 345 | 6.1 | 763 | 4.5 | 787 | 6.2 | 2,607 | 7.8 | |
Ciprofloxacin | 2,693 | 88.5 | 1,604 | 90.6 | 1,176 | 80.4 | 1,326 | 82.9 | 1,544 | 91.8 | 4,068 | 78.2 | |
Gentamicin | 3,162 | 93.5 | 1,800 | 93.6 | 1,184 | 83.5 | 1,367 | 84.2 | 1,624 | 93.6 | 4,940 | 84.8 | |
Imipenem | 2,948 | 100 | 1,638 | 100 | 1,078 | 100 | 869 | 100 | 1,009 | 99.9 | 3,636 | 100 | |
Levofloxacin | NA | NA | 778 | 93.1 | 130 | 89.2 | NA | NA | 237 | 90.3 | 3,799 | 77.6 | |
Piperacillin-tazobactam | 2,154 | 94.2 | 1,850 | 94.8 | 531 | 94.9 | 681 | 95.5 | 1,222 | 95.7 | 3,226 | 93.1 | |
TMP-SMX | 3,034 | 83.0 | 1,881 | 85.7 | 1,124 | 67.8 | 1,372 | 70.1 | 1,673 | 87.2 | 4,880 | 74.7 | |
H. influenzae | Amoxicillin-clavulanate | 3,612 | 100 | 2,006 | 100 | 424 | 100 | 2,327 | 100 | 401 | 100 | 1,138 | 99.8 |
Ampicillin | 790 | 71.3 | 2,293 | 93.5 | 1,041 | 91.1 | 2,400 | 78.8 | 2,901 | 78.6 | 2,857 | 63.0 | |
Cefepime | NA | NA | NA | NA | NA | NA | 513 | 100 | NA | NA | 84 | 100 | |
Cefotaxime | 3,183 | 100 | 2,071 | 100 | 448 | 100 | 2,308 | 100 | 810 | 100 | 1,129 | 100 | |
Ceftazidime | NA | NA | 1,610 | 100 | 309 | 100 | NA | NA | NA | NA | 108 | 100 | |
Ceftriaxone | 209 | 100 | 50 | 100 | 449 | 100 | 142 | 100 | 293 | 100 | 2,051 | 100 | |
Cefuroxime | 737 | 71.4 | 2,052 | 98.8 | 150 | 95.3 | 1,493 | 98.3 | 1,838 | 99.4 | 2,227 | 96.1 | |
Ciprofloxacin | 538 | 100 | 2,080 | 100 | 580 | 100 | 1,756 | 100 | 533 | 100 | 352 | 100 | |
Gentamicin | 3,001 | 74.4 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | |
Imipenem | NA | NA | 1,996 | 100 | 277 | 100 | 808 | 100 | NA | NA | 194 | 100 | |
Levofloxacin | NA | NA | 769 | 100 | 371 | 100 | 343 | 100 | 104 | 100 | 1,163 | 100 | |
TMP-SMX | 3,327 | 73.4 | 2,024 | 84.5 | 1,037 | 84.4 | 1,987 | 58.1 | 2,345 | 81.0 | 2,756 | 80.9 |
Data are cumulative for 2000 to 2001.
NA, not available, <50 results were available.