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. 2003 Oct;47(10):3089–3098. doi: 10.1128/AAC.47.10.3089-3098.2003

TABLE 1.

Susceptibilities of nine species of gram-negative bacteria isolated from hospitalized patients in four European countries, Canada, and the United States to antimicrobialsa

Organism Antimicrobial agent France
Germany
Italy
Spain
Canada
United States
No. of isolates % Susceptible No. of isolates % Susceptible No. of isolates % Susceptible No. of isolates % Susceptible No. of isolates % Susceptible No. of isolates % Susceptible
E. coli Amikacin 75,385 99.4 25,704 99.8 22,884 99.2 17,232 99.8 18,024 99.6 74,220 99.5
Amoxicillin-clavulanate 83,690 69.9 6,205 78.8 21,667 80.6 24,101 85.8 19,286 79.6 45,434 81.2
Ampicillin 33,822 53.6 21,339 58.3 23,263 56.5 19,705 39.2 52,354 64.6 135,321 57.9
Cefepime 30,427 99.6 16,758 99.2 8,955 99.2 12,137 98.4 1,636 99.3 54,041 99.1
Cefotaxime 82,657 99.6 44,149 99.1 19,542 97.1 22,991 98.2 18,927 97.0 54,268 98.3
Cefpirome 14,045 99.6 NAb NA NA NA NA NA NA NA NA NA
Ceftazidime 77,457 99.1 22,800 98.9 23,216 96.5 21,303 98.1 39,585 98.7 81,300 97.0
Ceftriaxone 7,278 99.5 3,193 99.8 10,410 96.7 793 97.4 36,293 98.6 97,940 98.5
Cefuroxime 11,384 92.8 35,157 91.9 7,643 87.0 14,507 91.9 20,340 92.9 54,084 91.7
Ciprofloxacin 64,199 94.0 36,898 88.4 24,201 84.7 23,473 80.5 45,854 93.2 110,811 92.4
Gentamicin 84,261 96.7 41,428 95.2 26,319 92.8 23,967 91.1 46,778 94.8 135,528 95.0
Imipenem 75,852 100 37,172 100 20,230 100 13,254 100 32,838 100 87,433 100
Levofloxacin NA NA 16,582 89.8 2,269 85.2 169 75.2 5,974 90.3 100,223 91.6
Piperacillin-tazobactam 52,063 97.0 42,439 96.5 12,857 96.8 10,674 96.5 37,473 96.6 70,784 95.3
TMP-SMX 82,535 78.6 42,715 73.2 25,640 74.4 24,379 67.6 52,224 83.5 135,210 80.7
K. pneumoniae Amikacin 7,704 96.9 5,915 99.3 4,888 94.2 2,290 98.9 5,663 99.6 28,688 98.4
Amoxicillin-clavulanate 8,382 82.6 1,130 76.8 4,658 79.5 3,158 87.0 5,950 93.1 16,734 90.1
Ampicillin 3,249 0.6 4,424 0.9 4,126 1.4 2,639 0.9 14,605 1.0 46,943 1.3
Cefepime 3,409 95.8 3,925 95.1 1,629 96.6 1,710 87.0 574 98.8 23,462 96.7
Cefotaxime 8,378 96.1 10,088 93.8 4,135 90.4 3,052 91.3 5,919 98.3 21,812 93.6
Cefpirome 1,360 92.8 NA NA NA NA NA NA NA NA NA NA
Ceftazidime 8,105 94.4 5,299 92.4 5,204 83.9 2,823 90.9 11,573 98.4 33,261 90.9
Ceftriaxone 476 90.6 461 98.7 2,695 86.6 119 94.1 9,902 98.7 37,426 94.5
Cefuroxime 1,107 81.4 8,524 86.3 1,499 72.3 1,858 89.1 6,672 90.0 20,816 81.8
Ciprofloxacin 6,889 92.7 8,722 87.2 5,339 91.6 3,032 95.5 13,276 94.8 40,605 92.1
Gentamicin 8,396 97.2 9,631 93.7 5,393 90.1 3,177 89.1 13,837 97.5 49,694 94.1
Imipenem 8,007 100 9,265 100 4,772 100 1,809 100 9,430 100 35,247 100
Levofloxacin NA NA 4,065 93.1 588 92.0 NA NA 2,153 94.8 37,636 92.9
Piperacillin-tazobactam 5,626 92.9 9,893 86.2 2,387 89.7 1,362 89.3 10,959 93.9 30,227 89.5
TMP-SMX 8,140 87.5 9,890 83.3 5,174 82.9 3,193 85.5 14,726 92.5 49,187 89.1
K. oxytoca Amikacin 3,624 98.4 2,990 99.8 795 98.0 840 99.6 1,475 99.8 4,710 99.2
Amoxicillin-clavulanate 3,887 82.7 444 79.1 727 83.9 1,216 84.5 1,447 90.5 2,560 83.5
Ampicillin 1,707 0.7 2,071 3.7 882 3.5 933 2.1 3,598 0.9 7,624 1.2
Cefepime 1,642 97.1 1,815 94.0 602 98.5 563 94.1 110 99.1 3,955 96.5
Cefotaxime 3,879 97.6 4,979 92.7 623 95.5 1,170 96.2 1,620 96.7 3,933 93.1
Cefpirome 748 96.4 NA NA NA NA NA NA NA NA NA NA
Ceftazidime 3,735 98.7 2,555 94.5 929 88.7 1,160 96.8 2,814 98.1 5,790 92.4
Ceftriaxone 291 83.5 327 99.7 518 88.6 NA NA 2,430 97.0 6,133 90.6
Cefuroxime 506 80.6 4,186 80.4 512 75.6 624 84.1 1,791 89.1 4,080 78.6
Ciprofloxacin 3,298 92.5 4,122 88.1 984 93.6 1,195 94.2 3,277 97.3 6,902 91.9
Gentamicin 3,892 96.4 4,818 97.8 993 92.6 1,215 97.9 3,444 97.0 8,162 92.4
Imipenem 3,642 100 4,562 100 837 100 615 100 2,315 100 5,932 100
Levofloxacin NA NA 1,802 92.8 284 95.8 NA NA 492 98.4 5,751 93.1
Piperacillin-tazobactam 2,688 87.2 4,856 80.6 766 88.0 525 89.5 2,716 93.6 4,964 86.2
TMP-SMX 3,769 92.1 4,799 88.9 919 90.4 1,218 91.5 3,637 95.7 8,015 91.0
E. cloacae Amikacin 6,230 97.9 3,838 99.3 2,314 96.6 1,935 99.6 3,197 99.6 15,154 98.3
Amoxicillin-clavulanate 6,410 3.4 814 5.4 2,106 4.8 2,509 1.9 2,742 4.4 7,442 3.5
Ampicillin 2,470 2.8 3,242 9.0 1,941 7.1 1,976 4.3 6,823 1.6 22,307 2.7
Cefepime 3,335 91.7 2,746 96.5 1,245 93.0 1,954 93.8 298 97.3 13,595 92.2
Cefotaxime 6,463 71.3 6,777 72.8 2,145 56.8 1,866 78.8 3,254 75.7 13,373 63.8
Cefpirome 1,241 79.5 NA NA NA NA NA NA NA NA NA NA
Ceftazidime 6,359 70.6 4,096 68.5 2,732 57.5 1,846 74.0 5,427 79.3 18,661 64.9
Ceftriaxone 593 52.8 446 86.8 1,584 61.1 88 72.7 4,821 78.4 18,879 66.9
Cefuroxime 790 32.2 5,553 13.3 979 24.2 1,519 26.3 3,775 40.7 11,373 32.7
Ciprofloxacin 5,657 85.7 5,754 90.5 2,774 77.7 2,479 96.0 6,486 93.6 20,019 87.3
Gentamicin 6,456 89.8 6,449 95.5 2,797 77.1 2,514 99.0 6,652 96.2 24,286 89.5
Imipenem 6,273 100 6,268 100 2,569 100 1,640 100 4,660 100 19,108 100
Levofloxacin NA NA 2,806 92.3 620 68.6 NA NA 1,098 92.3 18,087 88.7
Piperacillin-tazobactam 5,006 73.6 6,682 73.4 1,475 64.3 1,302 74.3 5,427 77.2 15,129 70.0
TMP-SMX 6,202 90.7 6,571 93.0 2,623 86.3 2,527 95.0 6,890 93.2 23,724 86.9
E. aerogenes Amikacin 3,751 71.8 782 99.9 1,241 89.8 503 98.6 805 99.6 6,088 98.5
Amoxicillin-clavulanate 3,996 2.8 198 1.5 1,164 6.4 622 4.0 771 7.1 3,408 5.7
Ampicillin 1,727 0.4 589 2.0 1,013 2.9 531 3.8 1,820 2.1 9,814 2.9
Cefepime 2,327 85.3 499 98.0 556 94.1 519 95.6 NA NA 5,441 95.8
Cefotaxime 4,029 48.2 1,291 79.0 1,024 58.6 511 74.2 816 80.9 5,335 72.2
Cefpirome 1,131 74.1 NA NA NA NA NA NA NA NA NA NA/PICK>
Ceftazidime 4,051 31.2 705 59.9 1,362 42.3 490 67.1 1,528 83.0 7,853 68.9
Ceftriaxone 404 32.7 103 58.3 780 52.4 NA NA 1,310 85.3 8,138 73.4
Cefuroxime 689 16.4 974 57.6 456 27.0 437 42.8 953 66.4 4,853 55.9
Ciprofloxacin 3,703 34.2 1,116 91.9 1,380 62.1 605 91.1 1,744 94.3 8,655 93.4
Gentamicin 4,028 95.3 1,178 98.3 1,382 87.6 636 96.5 1,798 99.1 10,564 95.5
Imipenem 4,003 100 1,201 100 1,255 100 476 100 1,300 100 7,949 100
Levofloxacin NA NA 568 94.9 269 57.3 NA NA 272 92.7 7,875 94.4
Piperacillin-tazobactam 2,995 45.5 1,277 69.5 758 59.5 377 67.4 1,480 81.4 6,333 72.8
TMP-SMX 3,910 52.7 1,265 94.2 1,316 61.9 637 92.0 1,847 97.0 10,325 95.7
P. mirabilis Amikacin 11,063 97.5 4,979 99.8 4,728 99.0 2,804 99.5 2,476 99.7 13,935 99.3
Amoxicillin-clavulanate 11,920 77.9 1,157 96.7 4,457 83.8 3,906 94.8 3,240 93.9 6,978 96.5
Ampicillin 4,608 60.5 3,876 69.6 4,200 42.6 3,214 60.9 7,070 82.2 23,265 83.5
Cefepime 4,625 98.9 3,368 99.6 1,594 94.2 1,995 99.0 242 96.7 9,735 98.3
Cefotaxime 11,860 99.1 8,504 99.3 4,069 71.9 3,762 99.7 2,614 99.2 10,232 99.4
Cefpirome 1,874 97.8 NA NA NA NA NA NA NA NA NA NA
Ceftazidime 11,298 98.9 4,624 99.1 4,811 87.8 3,464 99.4 5,659 99.1 14,604 98.4
Ceftriaxone 635 99.7 568 98.8 1,846 81.0 91 98.9 5,141 99.5 17,912 99.5
Cefuroxime 1,488 95.2 6,893 97.6 1,358 57.2 2,264 98.1 2,800 98.0 9,246 97.2
Ciprofloxacin 9,866 85.8 7,319 89.1 4,963 73.2 3,833 89.3 6,349 92.4 18,586 84.6
Gentamicin 12,006 92.7 7,930 92.6 5,007 64.9 3,921 89.7 6,653 93.5 23,429 91.4
Imipenem 9,739 99.9 7,168 100 4,197 100 2,057 100 4,661 100 15,453 100
Levofloxacin NA NA 3,336 93.1 390 77.2 NA NA 929 98.5 18,137 85.5
Piperacillin-tazobactam 7,840 99.2 8,456 98.8 2,077 98.2 1,739 99.4 5,344 97.6 13,618 97.7
TMP-SMX 11,595 80.7 8,040 71.8 4,854 54.9 3,952 63.7 7,061 82.0 23,319 83.6
S. marcescens Amikacin 2,180 90.8 1,768 98.8 1,087 97.4 705 98.0 1,775 99.1 8,296 98.2
Amoxicillin-clavulanate 2,229 2.9 447 2.7 981 2.2 908 5.7 1,661 2.9 3,757 1.6
Ampicillin 906 2.0 1,270 7.4 858 7.0 765 8.2 3,612 11.1 12,611 5.9
Cefepime 1,274 98.3 1,212 98.6 610 98.2 754 97.6 133 97.7 7,313 96.8
Cefotaxime 2,252 81.0 2,827 91.2 930 85.7 736 92.1 1,782 93.5 7,194 85.5
Cefpirome 526 97.2 NA NA NA NA NA NA NA NA NA NA
Ceftazidime 2,214 95.8 1,808 92.1 1,279 87.7 673 94.5 3,064 96.3 10,480 89.4
Ceftriaxone 322 65.5 316 53.8 800 85.3 NA NA 2,594 95.7 10,511 90.6
Cefuroxime 296 1.4 2,208 0.6 453 1.8 540 1.9 1,930 1.9 6,228 0.7
Ciprofloxacin 2,034 76.3 2,659 66.2 1,293 88.5 915 90.7 3,559 85.4 11,138 89.5
Gentamicin 2,269 90.0 2,472 90.8 1,294 96.0 928 97.1 3,579 94.0 13,443 94.2
Imipenem 2,194 100 2,794 100 1,252 100 614 100 2,514 100 10,591 100
Levofloxacin NA NA 1,288 83.2 298 96.3 NA NA 563 92.2 10,233 93.5
Piperacillin-tazobactam 1,733 81.5 2,897 85.7 726 94.1 503 91.9 3,125 92.8 9,245 87.8
TMP-SMX 2,105 80.5 2,715 83.7 1,130 87.4 930 96.0 3,671 92.8 13,192 95.5
M. morganii Amikacin 2,975 98.8 1,061 99.6 1,098 98.7 1,041 99.6 666 99.7 3,090 99.0
Amoxicillin-clavulanate 3,128 1.4 254 3.9 1,015 2.9 1,356 1.3 738 1.9 1,515 3.8
Ampicillin 1,092 0.5 871 1.3 916 1.8 1,120 0.8 1,659 1.7 4,897 3.4
Cefepime 1,452 98.1 790 96.3 367 99.2 1,071 97.7 52 100 2,555 97.5
Cefotaxime 3,154 87.8 1,930 89.3 903 69.3 996 89.8 717 87.3 2,441 81.8
Cefpirome 560 93.8 NA NA NA NA NA NA NA NA NA NA
Ceftazidime 3,051 85.5 1,017 86.1 1,160 76.6 975 85.4 1,318 83.5 3,559 75.7
Ceftriaxone 220 90.5 90 95.6 558 86.9 64 96.9 1,224 96.6 3,981 91.9
Cefuroxime 437 8.0 1,627 4.1 345 6.1 763 4.5 787 6.2 2,607 7.8
Ciprofloxacin 2,693 88.5 1,604 90.6 1,176 80.4 1,326 82.9 1,544 91.8 4,068 78.2
Gentamicin 3,162 93.5 1,800 93.6 1,184 83.5 1,367 84.2 1,624 93.6 4,940 84.8
Imipenem 2,948 100 1,638 100 1,078 100 869 100 1,009 99.9 3,636 100
Levofloxacin NA NA 778 93.1 130 89.2 NA NA 237 90.3 3,799 77.6
Piperacillin-tazobactam 2,154 94.2 1,850 94.8 531 94.9 681 95.5 1,222 95.7 3,226 93.1
TMP-SMX 3,034 83.0 1,881 85.7 1,124 67.8 1,372 70.1 1,673 87.2 4,880 74.7
H. influenzae Amoxicillin-clavulanate 3,612 100 2,006 100 424 100 2,327 100 401 100 1,138 99.8
Ampicillin 790 71.3 2,293 93.5 1,041 91.1 2,400 78.8 2,901 78.6 2,857 63.0
Cefepime NA NA NA NA NA NA 513 100 NA NA 84 100
Cefotaxime 3,183 100 2,071 100 448 100 2,308 100 810 100 1,129 100
Ceftazidime NA NA 1,610 100 309 100 NA NA NA NA 108 100
Ceftriaxone 209 100 50 100 449 100 142 100 293 100 2,051 100
Cefuroxime 737 71.4 2,052 98.8 150 95.3 1,493 98.3 1,838 99.4 2,227 96.1
Ciprofloxacin 538 100 2,080 100 580 100 1,756 100 533 100 352 100
Gentamicin 3,001 74.4 NA NA NA NA NA NA NA NA NA NA
Imipenem NA NA 1,996 100 277 100 808 100 NA NA 194 100
Levofloxacin NA NA 769 100 371 100 343 100 104 100 1,163 100
TMP-SMX 3,327 73.4 2,024 84.5 1,037 84.4 1,987 58.1 2,345 81.0 2,756 80.9
a

Data are cumulative for 2000 to 2001.

b

NA, not available, <50 results were available.