TABLE 2.
Distribution of AMB in kidney, liver, spleen, heart, and lung 24 h after administration of a single dose of DOC-AMB and a single oral gavage of different AMB formulations to male Sprague-Dawley rats
| Tissue | AMB distribution in tissue (μg of AMB/g of tissue) after administration ofa:
|
|||||
|---|---|---|---|---|---|---|
| DOC-AMB
|
ABLC (50) | Intralipid-AMB (50) | Peceol-AMB (50) | Peceol-AMB (5) | ||
| i.v. (1)b | Oral (50) | |||||
| Kidney | 9.1 ± 1.1 | 9.0 ± 0.5 | NDc | ND | ND | ND |
| Liver | ND | ND | ND | 13.4 ± 3.5 | 10.9 ± 2.4 | 6.1 ± 0.2 |
| Spleen | ND | ND | ND | ND | 76.5 ± 0.7 | ND |
| Heart | ND | ND | 45.9 ± 34.5 | ND | 12.8 ± 3.0 | ND |
| Lung | 47 ± 8.7 | 731 ± 602d | 558 ± 48d | 43 ± 2 | ND | ND |
a
Data presented as means ± standard deviation (n = 6).
b
Values in parentheses are the AMB doses in milligram per kilogram.
c
ND, not detectable.
d
Significantly different from AMB concentration in lung tissue after DOC-AMB i.v. administration (AMB at 1 mg/kg) (P < 0.05).