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Steady-state levofloxacin pharmacokinetic parameters in plasma during i.v. administration of 500 mg b.i.d. in 10 ICU patients with external ventriculostomies
| Parameter | Dose (mg/kg/12 h) | Cmax ss (mg/liter) | Vss (liters/kg) | t1/2β (h) | CL (ml/min/kg) | AUC0-τ (mg · h/liter) |
|---|---|---|---|---|---|---|
| Mean ± SD | 7.17 ± 1.30 | 10.45 ± 3.54 | 1.13 ± 0.30 | 5.51 ± 1.36 | 2.75 ± 1.18 | 47.69 ± 17.24 |
| CVa (%) | 18 | 34 | 27 | 25 | 43 | 36 |
CV, coefficient of variation.
