TABLE 4.

Levofloxacin pharmacokinetic and pharmacodynamic aspects in CSF of 10 patients with external ventriculostomy

Patient no.	Cmax ss CSF (mg/liter)	Tmax CSF (h)	AUC0-τ CSF (mg · h/liter)	CSF to plasma AUC0-τ ratio	CSF to plasma Cmax ss ratio	t1/2z CSF (h)	PD BPCSF for AUC0-24 (mg/liter)	PD BPCSF for Cmax (mg/liter)
1	2.66	2	21.05	0.69	0.41	4.91	0.34	0.22
2	2.55	2	20.31	0.79	0.43	4.99	0.32	0.21
3	6.14	1.5	42.69	0.83	0.79	7.70	0.68	0.50
4	3.21	3	28.68	0.66	0.43	6.52	0.46	0.26
5	3.63	2	21.14	0.73	0.49	6.02	0.34	0.30
6	5.52	2	41.36	0.68	0.52	8.31	0.66	0.45
7	3.31	5	31.02	0.77	0.51	8.15	0.50	0.27
8	4.68	5	45.28	0.64	0.39	8.66	0.72	0.38
9	5.31	3	48.73	0.65	0.32	9.17	0.78	0.44
10	3.56	1.5	33.90	0.67	0.39	5.74	0.54	0.29
Mean ± SD	4.06 ± 1.26	2.70 ± 1.32	33.42 ± 10.69	0.71 ± 0.07	0.47 ± 0.13	7.02 ± 1.57	0.53 ± 0.17	0.33 ± 0.10
CVa (%)	31	49	32	9	27	22	32	31

^aCV, coefficient of variation.