TABLE 2.
Final population pharmacokinetic parameters for ciprofloxacina
| Population parameter | CL (liters/h)
|
V (liters)
|
k23 (h−1) (θ6) | k32 (h−1) (θ7) | ka (h−1) (θ8) | F (θ9) | Lag time (h) (θ10) | |||
|---|---|---|---|---|---|---|---|---|---|---|
| θ4 | θ3 | θ5 | θ1 | θ2 | ||||||
| Population group (n = 37)b | ||||||||||
| Population mean | 1.93 | 0.469 | 16.7 | 2.17 | 0.908 | 0.340 | 0.429 | 0.423 | 0.852 | 0.798 |
| Interindividual variability (% CV) | 103.4 | 73.1 | 59.5 | 61.1 | 77.9 | 36.4 | 37.3 | |||
| All patients (n = 55)c | ||||||||||
| Population mean | 2.01 | 0.402 | 17.3 | 1.82 | 0.958 | 0.417 | 0.473 | 0.432 | 0.862 | 0.698 |
| Interindividual variability (% CV) | 96.5 | 76.9 | 24.1 | 50.6 | 102.5 | 32.1 | 54.8 | |||
a
CL = [θ3 + age · θ4] + θ5 · STAT (where STAT is the patient's clinical status); V = θ1 · weightθ2.
b
Intraindividual variability was 29.7%, and the objective function was 2,848.8.
c
Intraindividual variability was 34.3%, and the objective function was 4,197.3.