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Pharmacokinetic parameters for patients in the validation groupa
| Parameter | Age (yr) | Wt (kg) | CL (liters/h) | t1/2ka (h) | Vβ (liters) | t1/2β (h) | F | Lag time (h) |
|---|---|---|---|---|---|---|---|---|
| Minimum | 0.005 | 1.37 | 0.13 | 0.49 | 3.26 | 2.15 | 0.67 | 0.40 |
| Maximum | 11.0 | 29.0 | 38.8 | 2.39 | 175 | 17.9 | 1.08 | 1.87 |
| Mean | 3.63 | 13.5 | 12.6 | 1.58 | 54.1 | 5.51 | 0.84 | 0.85 |
| Interindividual variability (% CV) | 114 | 73.1 | 109 | 25.2 | 88.5 | 76.2 | 11.5 | 33.2 |
CV, coefficient of variation; t1/2ka, absorption half-life.
