FIG. 1.

In vivo bioluminescence monitoring of S. aureus in the mouse model of biofilm infection during treatment with ciprofloxacin, tobramycin, or rifampin. The total number of photons detected over the infected catheter per second was determined by using an IVIS camera and was plotted with respect to time. Two catheters were implanted in each mouse, and each datum point is the mean ± standard deviation for two to three mice. Arrows indicate the days of antibiotic administration. The data are the averages of results from three separate experiments.