TABLE 1.
MICs of antimicrobial agents against K. pneumoniae strains with different patterns of porin expression
| Strain | Porin(s) | MIC (μg/ml)a
|
|||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FOX | CTT | CAZ | CTX | FEP | PIR | IPM | MEM | CIP | CLX | AMK | GEN | TET | CHL | ||
| CSUB10S | OmpK36 | 2 | 0.06 | 256 | 8 | 2 | 4 | 0.125 | 0.03 | 0.5 | 0.06 | 1 | 4 | 2 | 16 |
| CSUB10R | None | 128 | 32 | >512 | 512 | 512 | 512 | 1 | 4 | 4 | 0.125 | 1 | 8 | 4 | 64 |
| CSUB10R/pSHA16K | OmpK35 | 1 | 0.03 | 2 | 0.5 | 0.125 | 0.5 | 0.125 | 0.03 | 0.25 | 0.06 | 0.5 | 4 | 1 | 8 |
| CSUB10R/pSHA25K | OmpK36 | 2 | 0.125 | 256 | 4 | 0.5 | 4 | 0.25 | 0.03 | 0.5 | 0.125 | 0.5 | 4 | 1 | 16 |
| CSUB10S/pSHA16K | OmpK35 and OmpK36 | 1 | 0.03 | 4 | 1 | 0.125 | 0.5 | 0.125 | 0.03 | 0.5 | 0.06 | 1 | 4 | 1 | 8 |
| CSUB10R/pKSK | None | 128 | 16 | >512 | 256 | 128 | 256 | 1 | 4 | 2 | 0.125 | 1 | 8 | 2 | 64 |
a
Abbreviations: FOX, cefoxitin; CTT, cefotetan; CAZ, ceftazidime; CTX, cefotaxime; FEP, cefepime; PIR, cefpirome; IPM, imipenem; MEM, meropenem; CIP; ciprofloxacin; CLX, clinafloxacin; AMK, amikacin; GEN, gentamicin; TET, tetracycline; CHL, chloramphenicol.