TABLE 2.
Peptide-PMO conjugates
Name | Target | PMO end attached to peptide | Cross-linker | Base sequence (5′→3′)a |
---|---|---|---|---|
P150 | c-myc | 3′, 5′, and 3′ + 5′ KFFKFFKFFKC | SPDP | ACG TTG AGG GGC ATC GTC GC |
P152 | c-myc | 3′, 5′, and 3′ + 5′ KFFKFFKFFKC | GMBS | ACG TTG AGG GGC ATC GTC GC |
P173 | c-myc | 3′ KFFKFFKFFKC | SPDP | ACG TTG AGG GGC ATC GTC GC |
P187 | c-myc control | 3′ KFFKFFKFFKC | GMBS | ACT GTG AGG GCG ATC GCT GC |
3 + 5′KFC-lacI | lacI | 3′, 5′, and 3′ + 5′ KFFKFFKFFKC | GMBS | TTC ACA TTC ACC ACC CTG AA |
3 + 5′KFC-lacI-scr | lacI control | 3′, 5′, and 3′ + 5′ KFFKFFKFFKC | GMBS | ATC CTC CCA ACT TCG ACA TA |
3′KFC-lacI | lacI | 3′ KFFKFFKFFKC | GMBS | TTC ACA T TC ACC ACC CTG AA |
3′KFC9-lacI-scr | lacI control | 3′ KFFKFFKFFKC | GMBS | ATC CTC CCA ACT TCG ACA TA |
5′KFC-lacI | lacI | 5′ KFFKFFKFFKC | GMBS | TTC ACA TTC ACC ACC CTG AA |
5′KFC-lacI-scr | lacI control | 5′ KFFKFFKFFKC | GMBS | ATC CTC CCA ACT TCG ACA TA |
rTat-lacI | lacI | 5′ CRRRQRRKKR | GMBS | TTC ACA TTC ACC ACC CTG AA |
rTat-lacI-scr | lacI control | 5′ CRRRQRRKKR | GMBS | ATC CTC CCA ACT TCG ACA TA |
Mismatched bases are underlined. The complement of the start codon is shown in boldface type.