TABLE 1.
Activities of pyridine oxide derivatives against different HIV strains in CEM cell cultures
| Compound | EC50 (μg/ml)a
|
CC50 (μg/ml)a | |||||
|---|---|---|---|---|---|---|---|
| HIV-1
|
HIV-2
|
||||||
| IIIB | RF | MN | HE | ROD | EHO | ||
| JPL-10 | 5.3 ± 2.6 | 7.2 ± 2.6 | 10 ± 1 | 11 ± 4 | 10 ± 1 | 14 ± 1 | 31 ± 6 |
| JPL-30 | 5.9 ± 3.0 | 10 ± 1 | 40 ± 4 | 38 ± 2 | 40 ± 4 | 44 ± 5 | 70 ± 20 |
| JPL-44 | 8.0 ± 0.8 | 9.0 ± 2.0 | 9.4 ± 2.0 | 11 ± 1 | 8.0 ± 1.6 | 12 ± 2 | 30 ± 6 |
| JPL-88 | 2.4 ± 0.1 | 12 ± 1 | 7.6 ± 0.5 | 5.8 ± 2.9 | 1.5 ± 0.1 | 2.1 ± 0.4 | 35 ± 8 |
| JPL-153 | 2.0 ± 0.5 | 10 ± 1 | 7.6 ± 0.5 | 4.0 ± 1.9 | 2.0 ± 0.2 | 2.4 ± 0.3 | 31 ± 8 |
a
Data represent the averages ± standard deviation for at least three independent experiments.