TABLE 2.
Effect of treatment with CDV on mortality of BALB/c mice inoculated i.n. with VV-WR
| Treatment | Mortality rate (%) | P | MDD | P |
|---|---|---|---|---|
| Placebo-saline | 15/15 (100) | 6.7 | ||
| CDV | ||||
| +48 h | ||||
| 6.7 mg/kg | 0/15 (0) | <0.001 | ||
| 2.2 mg/kg | 1/15 (7) | <0.001 | 7 | NSa |
| 0.7 mg/kg | 6/15 (40) | <0.001 | 8.3 | NS |
| +72 h | ||||
| 6.7 mg/kg | 0/15 (0) | 0.001 | ||
| 2.2 mg/kg | 6/15 (40) | <0.01 | 7.3 | NS |
| 0.7 mg/kg | 10/15 (67) | 0.05 | 7.7 | NS |
| +96 h | ||||
| 6.7 mg/kg | 6/15 (40) | <0.01 | 8.5 | NS |
| 2.2 mg/kg | 15/15 (100) | NS | 8.3 | NS |
| 0.7 mg/kg | 15/15 (100) | NS | 7.5 | 0.03 |
a
NS, result not significant compared to that of the placebo control.