TABLE 3.

Effect of interval treatment with CDV on mortality of BALB/c mice inoculated i.n. with CV-BR

Treatmenta	Mortality rate (%)	P	MDD	P
Placebo
+24 h	16/16 (100)		9.2
+48 h	14/15 (93)		10.1
+72 h	14/14 (100)		9.3
CDV once daily
6.7 mg/kg +24 h	1/15 (7)	<0.001	9.0	NSb
6.7 mg/kg +48 h	0/15 (0)	<0.001
6.7 mg/kg +72 h	1/15 (7)	<0.001	11.0	0.07
2 mg/kg +24 h	1/16 (6)	<0.001	3.0	0.07
2 mg/kg +48 h	5/15 (33)	<0.01	14.2	NS
2 mg/kg +72 h	5/15 (33)	<0.001	15.4	0.001
CDV every 48 h
6.7 mg/kg +24 h	0/15 (0)	<0.001
6.7 mg/kg +48 h	1/15 (7)	<0.001	12.0	0.09
6.7 mg/kg +72 h	1/15 (7)	<0.001	15.0	0.07
2 mg/kg +24 h	4/15 (27)	<0.001	12.8	<0.001
2 mg/kg +48 h	7/15 (47)	<0.01	13.0	<0.01
2 mg/kg +72 h	8/15 (53)	<0.01	11.4	<0.01
CDV every 72 h
6.7 mg/kg +24 h	0/15 (0)	<0.001
6.7 mg/kg +48 h	5/15 (33)	<0.01	14.6	<0.01
6.7 mg/kg +72 h	0/15 (0)	<0.001
2 mg/kg +24 h	1/15 (7)	<0.001	21.0	0.07
2 mg/kg +48 h	14/15 (93)	NS	11.8	NS
2 mg/kg +72 h	11/15 (79)	NS	12.8	<0.001

^aCDV was prepared in sterile saline and delivered i.p. in 0.1-ml doses. The animals were treated once daily every other day or every third day for 7 days beginning at 24, 48, or 72 h after viral inoculation.

^bNS, result not significant compared to that of the placebo control.