TABLE 4.

Effect of single dose CDV on mortality of BALB/c mice inoculated i.n. with CV-BR

Treatmenta	Mortality rate (%)	P	MDD	P
None	12/15 (80)		10.5
Placebo, day +1	15/15 (100)		10.6
CDV
Day −5
100 mg/kg	8/15 (53)	<0.01	12.6	<0.05
30 mg/kg	12/15 (80)	NSb	12.3	0.07
10 mg/kg	9/15 (60)	<0.05	11.0	NS
3 mg/kg	14/15 (93)	NS	11.6	NS
Day −3
100 mg/kg	2/15 (13)	<0.001	10.5	NS
30 mg/kg	3/15 (20)	<0.001	11.3	NS
10 mg/kg	11/15 (73)	NS	11.5	NS
3 mg/kg	14/15 (100)	NS	10.6	NS
Day −1
100 mg/kg	1/15 (7)	<0.001	10.0	NS
30 mg/kg	4/15 (27)	<0.001	12.3	NS
10 mg/kg	5/15 (33)	<0.001	12.0	NS
3 mg/kg	8/15 (53)	<0.01	10.6	NS
Day +1
100 mg/kg	1/15 (7)	<0.001	9.0
30 mg/kg	4/15 (27)	<0.001	10.8	NS
10 mg/kg	7/15 (47)	<0.01	10.6	NS
3 mg/kg	12/15 (80)	NS	10.1	NS
Day +3
100 mg/kg	0/15 (0)	<0.001
30 mg/kg	3/15 (20)	<0.001	13.0	NS
10 mg/kg	4/15 (27)	<0.001	15.5	<0.05
3 mg/kg	13/15 (87)	NS	11.2	NS

^aCDV was prepared in sterile saline and delivered i.p. in 0.1-ml doses. The animals were treated one time only for each time period beginning on day −5, −3, or −1 before or day 1 or day 3 after viral inoculation.

^bNS, result not significant compared to that of the placebo control.