TABLE 5.

Effect of single-dose CDV on mortality of BALB/c mice inoculated i.n. with VV-WR

Treatmenta	Mortality rate (%)	P	MDD	P
None	15/15 (100)		9.1
Placebo, day +1	14/15 (93)		8.6
CDV
Day −5
100 mg/kg	1/15 (7)	<0.001	10.0	0.7
30 mg/kg	9/15 (60)	0.08	9.0	NSb
10 mg/kg	8/15 (53)	<0.05	8.8	NS
3 mg/kg	14/15 (93)	NS	8.5	NS
Day −3
100 mg/kg	2/15 (13)	<0.001	8.5	NS
30 mg/kg	7/15 (47)	0.01	9.1	NS
10 mg/kg	15/15 (100)	NS	8.4	NS
3 mg/kg	12/15 (80)	NS	8.3	NS
Day −1
100 mg/kg	0/15 (0)	<0.001
30 mg/kg	0/15 (0)	<0.001
10 mg/kg	2/15 (13)	<0.001	12.0	0.01
3 mg/kg	12/15 (80)	NS	8.6	NS
Day +1
100 mg/kg	0/15 (0)	<0.001
30 mg/kg	0/15 (0)	<0.001
10 mg/kg	0/15 (0)	<0.001
3 mg/kg	4/15 (27)	<0.001	9.0	NS
Day +3
100 mg/kg	2/15 (13)	<0.001	10.5	0.01
30 mg/kg	1/15 (7)	<0.001	8.0	NS
10 mg/kg	0/15 (0)	<0.001
3 mg/kg	8/15 (53)	<0.05	8.6	NS

^aCDV was prepared in sterile saline and delivered i.p. in 0.1-ml doses. The animals were treated one time only for each time period beginning day −5, −3, or −1 or day 1 or day 3 after viral inoculation.

^bNS, result not significant compared to that of the placebo control.