TABLE 6.

Effect of treatment with CDV on mortality of SCID mice inoculated i.p. with CV-BR or VV-WR

Virus	Treatment	Mortality rate (%)	P	MDD	P
CV-BR	Placebo-saline	15/15 (100)		8.3
	CDV
	+48 h
	20 mg/kg	15/15 (100)	NSa	17.3	<0.001
	6.7 mg/kg	15/15 (100)	NS	10.7	<0.05
	2.2 mg/kg	15/15 (100)	NS	8.0	NS
	+72 h
	20 mg/kg	14/15 (93)	NS	11.9	<0.01
	6.7 mg/kg	15/15 (100)	NS	10.0	NS
	2.2 mg/kg	15/15 (100)	NS	7.7	NS
VV-WR	Placebo-saline	10/10 (100)		12.7
	CDV
	+72 h
	20 mg/kg	10/10 (100)	NS	22.7	<0.001
	6.7 mg/kg	10/10 (100)	NS	19.9	<0.001
	2.2 mg/kg	10/10 (100)	NS	18.3	<0.001
	+96 h
	20 mg/kg	10/10 (100)	NS	19.6	0.001
	6.7 mg/kg	10/10 (100)	NS	17.9	<0.001
	2.2 mg/kg	10/10 (100)	NS	15.7	<0.05

^aNS, result not significant compared to that of the placebo control.