TABLE 7.
Lack of development of resistance to CDV in SCID mice infected with CV-BR and treated with CDV
Treatment | Sample type | CDV EC50 (μg/ml) | CDV EC50 mean ± SD |
---|---|---|---|
None | Virus stock | 13.3 ± 1.7 | |
Saline | |||
Day 7 | Lung | 10.7 | |
Day 10 | Lung | 11.2 | 11.3 ± 0.71 |
Day 14 | Lung | 12.1 | |
Day 7 | Liver | 11.8 | |
Day 10 | Liver | 11.1 | 11.6 ± 0.44 |
Day 14 | Liver | 11.9 | |
CDV | |||
Day 18 | Lung | 11.9 | |
Day 24 | Lung | 12.3 | |
Day 28 | Lung | 12.1 | 12.0 ± 0.67 |
Day 32 | Lung | 12.7 | |
Day 37 | Lung | 10.9 | |
Day 18 | Liver | 11.1 | |
Day 24 | Liver | 12.1 | |
Day 28 | Liver | 11.5 | 12.0 ± 0.84 |
Day 32 | Liver | 11.8 | |
Day 37 | Liver | 13.3 |