TABLE 2.
MIC-2s, MIC-0s, and MFCs of PNT against 10 clinical isolates of Fusarium spp. in RPMI and YNB media (NCCLS microdilution method M-38P)
| Fusarium sp. (no. of isolates) | RPMI medium
|
YNB medium
|
||||
|---|---|---|---|---|---|---|
| MIC50 (range, GMa)
|
MFC50 (range, GM) | MIC50 (range, GM)
|
MFC50 (range, GM) | |||
| MIC-2b | MIC-0c | MIC-2b | MIC-0c | |||
| F. solani (5) | 4g (2-4, 3.6)d | 32 (8-32, 24)e | >128 (8->128, 206.4)e | 1 (1-2, 1.4) | 8 (4-16, 10.4) | >128 (8->128, 206.4) |
| Non-F. solani (5) | 2 (1-2, 1.8)d | 8 (4-8, 6.4)e | 8 (4-16, 8.8)f | 0.5 (0.5-1.0, 0.6) | 1 (1-2, 1.2) | 8 (4-8, 6.4) |
a
GM, geometric mean.
b
P < 0.001 for MIC-2s of PNT against Fusarium spp. in RPMI medium versus those in YNB medium.
c
P < 0.05 for MIC-0s of PNT against Fusarium spp. in RPMI medium versus those in YNB medium.
d
P < 0.05 for MIC-2s of PNT against F. solani isolates versus those for non-F. solani Fusarium isolates.
e
P < 0.05 for MIC-0s of PNT against F. solani isolates versus those for non-F. solani Fusarium isolates.
f
P < 0.001 for MFCs of PNT against F. solani isolates versus those for non-F. solani Fusarium isolates.
g
Units are micrograms per milliliter throughout.