TABLE 4.
MIC-2s and MIC-0s of PNT against 10 clinical isolates of Fusarium spp. under different oxygen conditions in RPMI medium (NCCLS microdilution method M-38P)
| Fusarium sp. (no. of isolates) | MIC50e (range, GMa)
|
|||||
|---|---|---|---|---|---|---|
| Aerobic conditions
|
Microaerophilic conditions
|
Anaerobic conditions
|
||||
| MIC-2b,c | MIC-0d | MIC-2b | MIC-0 | MIC-2c | MIC-0d | |
| F. solani (5) | 4 (2-4, 3.6) | 32 (8-32, 24) | 2 (1-2, 1.8) | 16 (8-16, 12.8) | 1 (1-2, 1.2) | 8 (4-16, 8.8) |
| Non-F. solani (5) | 2 (1-2, 1.8) | 8 (4-8, 6.4) | 0.5 (0.5-1, 0.6) | 2 (1-2, 1.6) | 0.250 (0.125-0.500, 0.220) | 1.0 (0.5-1.0, 0.9) |
a
GM, geometric mean.
b
P < 0.05 for MIC-2s of PNT against Fusarium spp. under aerobic conditions versus those under microaerophilic conditions.
c
P < 0.001 for MIC-2s of PNT against Fusarium spp. under aerobic conditions versus those under anaerobic conditions.
d
P < 0.05 for MIC-0s of PNT against Fusarium spp. under aerobic conditions versus those under anaerobic conditions.
e
Units are micrograms per milliliter throughout.