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Survival of CD8−/− mice infected with C. neoformans after administration of mAbs. (A) CD8−/− mice were more susceptible than their parental C57BL/6J strain (P < 0.003). (B) Average survival times and standard deviations for the IgG1, IgG3, and PBS groups were 114.30 ± 59.60, 76.90 ± 44.67, and 35.30 ± 16.13 days, respectively. Both IgG1 (P < 0.001) and IgG3 (P < 0.03) mAbs significantly prolong animal survival.
