Table 1.

Organ cfu and serum GXM in CD4^−/− mice 6 days after cryptococcal infection

	Lung cfu, × 105	P ≤	Brain cfu, × 105	P ≤	GXM*, mg/ml	P ≤
No IFN-γ therapy
PBS	12.2 ± 0.9	0.0220†	26.0 ± 1.6	0.507†	1.4 ± 0.1	0.109†
IgG1	20.7 ± 2.6	0.0001‡	25.0 ± 2.7	0.001‡	1.5 ± 0.1	0.0001‡
IgG3	111.8 ± 14.1	0.0001§	34.2 ± 2.6	0.001§	2.5 ± 0.3	0.0001§
IFN-γ therapy
PBS	11.5 ± 1.8	0.012†	12.8 ± 2.6	0.001†	1.2 ± 0.2	0.0005†
IgG1	8.0 ± 0.9	0.0002‡	5.4 ± 1.8	0.0001‡	0.5 ± 0.2	0.0001‡
IgG3	33.6 ± 4.3	0.0001§	29.4 ± 3.7	0.0001§	2.3 ± 0.3	0.0003§

^*Value is expressed as mean ± SD. 

^†PBS vs. IgG1. 

^‡IgG1 vs. IgG3. 

^§IgG3 vs. PBS (unpaired Student’s t test).