TABLE 1.
Activity of UIC-94017 against HIV-1LAI and cytotoxicity of UIC-94017a
| Drug | IC50 (μM) | CC50 (μM) | Selectivity index |
|---|---|---|---|
| UIC-94017 | 0.003 ± 0.0001 | 74.4 ± 1.2 | 24,800 |
| SQV | 0.017 ± 0.003 | 11.3 ± 2.8 | 660 |
| APV | 0.036 ± 0.011 | >100 | >2,800 |
| IDV | 0.047 ± 0.008 | 70.3 ± 4.6 | 1,500 |
| NFV | 0.027 ± 0.004 | ND | ND |
| RTV | 0.045 ± 0.012 | ND | ND |
| LPV | 0.034 ± 0.006 | ND | ND |
a
MT-2 cells (2 × 103) were exposed to 100 TCID50s of HIV-1LAI and cultured in the presence of various concentrations of PIs, and the IC50s were determined by the MTT assay on day 7 of culture. All assays were conducted in duplicate, and the data shown represent mean ± 1 standard deviation derived from the results of three independent experiments. ND, not determined.