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Activity of megazol against wild-type and RAD51−/− T. brucei bloodstream formsa
| Drug | IC50 (μM)
|
|
|---|---|---|
| Wild type | RAD51−/− mutants | |
| Megazol | 0.13 ± 0.0025 | 0.029 ± 0.002 |
| Megazol with NAC | 0.13 ± 0.0020 | ND |
| Nifurtimox | 3.37 ± 0.19 | 3.40 ± 0.15 |
| Nifurtimox with NAC | 12.72 ± 1.1 | ND |
Values are means ± standard deviations (n = 3 independent experiments). The effect of 0.5 mM NAC was assessed by adding this concentration to wild-type cells only prior to addition of drug. ND, not determined.
