TABLE 1.
Correlation of linezolid MICs to the number of G2576T mutated 23S rRNA genes in E. faecalis JH2-2 mutants
Linezolid MIC (μg/ml) | No. of amplification products digested with MaeI/no. of colonies screened (%) | No. of G2576T mutated genes/total no. of 23S rRNA genes (%) |
---|---|---|
4 | 5/10 (50) | 2/4 (50) |
8 | 4/12 (33) | 2/4 (50) |
16 | 8/12 (67) | 3/4 (75) |
32 | 9/11 (81) | 3/4 (75) |
64 | 10/12 (83) | 3/4 (75) |
128 | 17/17 (100) | 4/4 (100) |