TABLE 1.

Comparative antibacterial activities

Species (resistance)a	No. of isolates	Antibiotic	MIC (μg/ml)
			Range	50%	90%
S. aureus (quinolone S)	16	ABT-492	≤0.002-0.008	0.004	0.008
		Trovafloxacin	0.008-0.015	0.015	0.03
		Levofloxacin	0.06-0.25	0.12	0.25
		Ciprofloxacin	0.25-0.5	0.25	0.5
S. aureus (quinolone R)	19	ABT-492	0.06-0.5	0.12	0.5
		Trovafloxacin	0.5-2	1	2
		Levofloxacin	4-32	8	16
		Ciprofloxacin	8-128	32	128
S. epidermidis (quinolone S)	10	ABT-492	≤0.008	≤0.008	≤0.008
		Trovafloxacin	≤0.008-0.06	0.03	0.03
		Levofloxacin	0.06-0.25	0.25	0.25
		Ciprofloxacin	0.12-0.25	0.12	0.25
CoNSb (quinolone R)	10	ABT-492	0.03-0.5	0.25	0.5
		Trovafloxacin	1-16	2	8
		Levofloxacin	4-128	8	64
		Ciprofloxacin	8->32	32	>128
S. pneumoniae (quinolone S)	29	ABT-492	0.004-0.03	0.008	0.015
		Trovafloxacin	0.015-0.06	0.03	0.03
		Levofloxacin	0.25-1	0.5	0.5
		Ciprofloxacin	1-8	1	2
S. pneumoniae (quinolone R)	30	ABT-492	0.004-0.5	0.06	0.12
		Trovafloxacin	0.12-16	4	8
		Levofloxacin	0.5-16	8	16
		Ciprofloxacin	2-64	32	64
S. pyogenes	16	ABT-492	0.004-0.03	0.008	0.015
		Trovafloxacin	0.03-0.12	0.06	0.12
		Levofloxacin	0.25-1	0.5	0.5
		Ciprofloxacin	0.25-1	0.5	0.5
Viridans group streptococci	10	ABT-492	0.004-0.03	0.008	0.015
		Trovafloxacin	0.06-0.5	0.12	0.25
		Levofloxacin	1-4	1	2
		Ciprofloxacin	2-16	2	4
E. faecalis (quinolone S)	13	ABT-492	0.015-0.03	0.03	0.03
		Trovafloxacin	0.06-0.25	0.12	0.12
		Levofloxacin	0.5-1	0.5	1
		Ciprofloxacin	0.25-1	0.5	1
E. faecalis (quinolone R)	12	ABT-492	0.06-1	0.25	0.5
		Trovafloxacin	0.25-16	4	16
		Levofloxacin	1-32	16	32
		Ciprofloxacin	2-128	64	128
E. faecium (quinolone S)	6	ABT-492	≤0.008-0.25	0.25
		Trovafloxacin	0.03-2	1
		Levofloxacin	0.5-2	1
		Ciprofloxacin	0.5-1	1
E. faecium (quinolone R)	14	ABT-492	0.25-64	4	32
		Trovafloxacin	0.5-32	4	32
		Levofloxacin	1-128	32	128
		Ciprofloxacin	2->128	128	>128
L. monocytogenes	15	ABT-492	0.06-0.12	0.12	0.12
		Trovafloxacin	0.12-0.25	0.25	0.25
		Levofloxacin	1	1	1
		Ciprofloxacin	1-2	1	1
E. coli (quinolone S)	20	ABT-492	0.008-0.06	0.015	0.015
		Trovafloxacin	0.004-0.03	0.008	0.03
		Levofloxacin	0.008-0.03	0.008	0.015
		Ciprofloxacin	0.004-0.008	0.004	0.008/PICK>
E. coli (quinolone R)	10	ABT-492	4-32	8	16
		Trovafloxacin	32->128	>128	>128
		Levofloxacin	16-128	32	64
		Ciprofloxacin	32->128	128	>128
Salmonella spp.	20	ABT-492	0.008-0.5	0.03	0.06
		Trovafloxacin	0.008-0.5	0.03	0.06
		Levofloxacin	0.015-1	0.06	0.06
		Ciprofloxacin	0.008-0.5	0.015	0.03
Shigella spp.	9	ABT-492	0.002-0.008
		Trovafloxacin	0.002-0.015
		Levofloxacin	0.004-0.015
		Ciprofloxacin	0.002-0.015
C. freundii	20	ABT-492	0.03->2	0.25	2
		Trovafloxacin	0.015-0.5	0.06	0.5
		Levofloxacin	0.015-0.25	0.12	0.25
		Ciprofloxacin	0.008-0.12	0.03	0.12
Klebsiella spp.c (quinolone S)	20	ABT-492	≤0.002-0.25	0.06	0.12
		Trovafloxacin	0.004-1	0.03	0.06
		Levofloxacin	0.015-1	0.03	0.06
		Ciprofloxacin	0.004-0.25	0.015	0.03
K. pneumoniae (quinolone R)	10	ABT-492	2-8	4	8
		Trovafloxacin	4->128	>128	>128
		Levofloxacin	8-64	32	64
		Ciprofloxacin	64->128	128	>128
P. mirabilis	19	ABT-492	0.008-0.25	0.015	0.12
		Trovafloxacin	0.12-1	0.5	1
		Levofloxacin	0.015-0.25	0.06	0.12
		Ciprofloxacin	0.015-0.12	0.03	0.12
Enterobacter spp.	20	ABT-492	≤0.004-0.06	0.015	0.03
		Trovafloxacin	0.008-0.25	0.03	0.06
		Levofloxacin	≤0.004-0.06	0.03	0.06
		Ciprofloxacin	≤0.004-0.03	0.008	0.015
Providencia spp.	20	ABT-492	0.015-0.25	0.06	0.25
		Trovafloxacin	0.12-1	0.25	0.5
		Levofloxacin	0.12-1	0.25	0.25
		Ciprofloxacin	0.015-0.5	0.06	0.25
S. marcescens	10	ABT-492	0.5-2	0.5	2
		Trovafloxacin	0.06-0.25	0.12	0.25
		Levofloxacin	0.015-0.12	0.06	0.12
		Ciprofloxacin	0.015-0.06	0.015	0.03
P. aeruginosa (quinolone S)	20	ABT-492	0.03-0.5	0.06	0.25
		Trovafloxacin	0.06-2	0.25	0.5
		Levofloxacin	0.06-2	0.25	0.5
		Ciprofloxacin	0.03-1	0.06	0.25
P. aeruginosa (quinolone R)	20	ABT-492	8->128	32	128
		Trovafloxacin	64->128	>128	>128
		Levofloxacin	32->128	64	>128
		Ciprofloxacin	16->128	64	128
B. cepacia	3	ABT-492	>8
		Trovafloxacin	8->8
		Levofloxacin	8->8
		Ciprofloxacin	8->8
S. maltophilia	7	ABT-492	≤0.008-2	1
		Trovafloxacin	0.03-0.5	0.5
		Levofloxacin	0.25-2	1
		Ciprofloxacin	0.25-4	2
H. influenzae (quinolone S)	25	ABT-492	≤0.002-0.008	≤0.002	0.004
		Trovafloxacin	≤0.002-0.015	0.004	0.015
		Levofloxacin	≤0.002-0.015	0.008	0.008
		Ciprofloxacin	≤0.002-0.008	0.004	0.008
H. influenzae (quinolone R)	6	ABT-492	≤0.004-0.12	≤0.004
		Trovafloxacin	0.06-4	0.5
		Levofloxacin	0.06-16	1
		Ciprofloxacin	0.03-16	1
M. catarrhalis	17	ABT-492	≤0.002-0.004	≤0.002	≤0.002
		Trovafloxacin	0.004-0.008	0.008	0.008
		Levofloxacin	0.008-0.03	0.015	0.03
		Ciprofloxacin	0.008-0.015	0.015	0.015
L. pneumophila	14	ABT-492	0.12	0.12	0.12
		Trovafloxacin	0.25	0.25	0.25
		Levofloxacin	0.5	0.5	0.5
		Ciprofloxacin	0.5-1	1	1
Legionella spp.	5	ABT-492	0.12	0.12
		Trovafloxacin	0.25	0.25
		Levofloxacin	0.5	0.5
		Ciprofloxacin	0.5-1	1
N. gonorrhoeae	10	ABT-492	≤0.004	≤0.004	≤0.004
		Trovafloxacin	≤0.004-0.03	≤0.004	0.03
		Levofloxacin	≤0.004-0.06	0.015	0.06
		Ciprofloxacin	≤0.004-0.06	≤0.004	0.008
H. pylori	45	ABT-492	0.015-0.12	0.03	0.12
		Trovafloxacin	0.03-0.5	0.12	0.25
		Levofloxacin	0.12-1	0.5	0.5
		Ciprofloxacin	0.06-1	0.25	0.5
M. avium	10	ABT-492	2-16	8	16
		Trovafloxacin	32-64	32	32
		Levofloxacin	16-64	32	64
		Ciprofloxacin	8-128	8	32
M. pneumoniae	18	ABT-492	0.25-0.5	0.5	0.5
		Trovafloxacin	0.12-0.25	0.12	0.25
		Levofloxacin	1-2	1	2
		Ciprofloxacin	1-2	2	2
C. trachomatis	2	ABT-492	0.03-0.06
		Trovafloxacin	0.06
		Levofloxacin	0.12-0.5
		Ciprofloxacin	0.5-1
B. fragilis	16	ABT-492	0.03-0.12	0.06	0.12
		Trovafloxacin	0.12-0.5	0.25	0.5
		Levofloxacin	1-2	2	2
		Ciprofloxacin	2-16	4	8
C. difficile	12	ABT-492	≤0.015	≤0.015	≤0.015
		Trovafloxacin	1	1	1
		Levofloxacin	2-4	2	4
		Ciprofloxacin	16	16	16
C. perfringens	12	ABT-492	≤0.015	≤0.015	≤0.015
		Trovafloxacin	0.06-0.25	0.12	0.12
		Levofloxacin	0.12-0.25	0.25	0.25
		Ciprofloxacin	0.5-1	0.5	1

^aS, susceptible; R, resistant.

^bCoNS, coagulase negative staphylococci; S. epidermidis (n = 8) and S. haemolyticus (n = 2).

^cK. pneumoniae (n = 15), K. oxytoca (n = 3), and K. rhinosceromatis (n = 2).