TABLE 4.

Effect of serum on antibacterial activity

Species	Resistance	Serum (50% [vol/vol])	MIC (μg/ml)
			ABT-492	Trovafloxacin	Ciprofloxacin
S. pneumoniae ATCC 6303	Susceptible	None	0.004	0.03	1
		Rat	0.03	0.25	0.5
		Human	0.008	0.06	1
S. pneumoniae 7215	Quinolone Ra	None	0.008	0.25	8
		Rat	0.25	2	4
		Human	0.03	0.5	8
S. pneumoniae 7257	Quinolone R	None	0.03	2	16
		Rat	0.5	>2	32
		Human	0.06	>2	16
H. influenzae 1435	Susceptible	None	≤0.001	0.004	≤0.008
		Rat	≤0.001	0.008	≤0.008
		Human	0.06	0.12	0.03
S. aureus NCTC 10649	Susceptible	None	≤0.001	0.004	0.12
		Rat	0.015	0.12	0.25
		Human	0.008	0.25	2
E. coli Juhl	Susceptible	None	0.008	0.008	≤0.008
		Rat	0.12	0.25	≤0.008
		Human	0.03	0.015	≤0.008
E. faecalis PIU 1967	Susceptible	None	0.015	0.06	0.25
		Rat	0.5	0.5	0.5
		Human	0.06	0.12	0.5

^aR, resistant.